Reaction Details Report a problem with these data
Target
Cytosolic phospholipase A2
Ligand
BDBM50085495
Substrate
n/a
Meas. Tech.
ChEBML_156221
IC50
69500±n/a nM
Citation
 Lucas, R; Ubeda, A; Payá, M; Alves, M; del Olmo, E; López, JL; San Feliciano, A Synthesis and enzyme inhibitory activities of a series of lipidic diamine and aminoalcohol derivatives on cytosolic and secretory phospholipases A2. Bioorg Med Chem Lett 10:285-8 (2000) [PubMed]  Article 
Target
Name:
Cytosolic phospholipase A2
Synonyms:
Cpla2 | PA24A_MOUSE | Pla2g4 | Pla2g4a
Type:
PROTEIN
Mol. Mass.:
85206.20
Organism:
Mus musculus
Description:
ChEMBL_156221
Residue:
748
Sequence:
MSFIDPYQHIIVEHQYSHKFTVVVLRATKVTKGTFGDMLDTPDPYVELFISTTPDSRKRTRHFNNDINPVWNETFEFILDPNQENVLEITLMDANYVMDETLGTATFPVSSMKVGEKKEVPFIFNQVTEMILEMSLEVCSCPDLRFSMALCDQEKTFRQQRKENIKENMKKLLGPKKSEGLYSTRDVPVVAILGSGGGFRAMVGFSGVMKALYESGILDCATYIAGLSGSTWYMSTLYSHPDFPEKGPEEINEELMKNVSHNPLLLLTPQKVKRYVESLWKKKSSGQPVTFTDIFGMLIGETLIQNRMSMTLSSLKEKVNAARCPLPLFTCLHVKPDVSELMFADWVEFSPYEIGMAKYGTFMAPDLFGSKFFMGTVVKKYEENPLHFLMGVWGSAFSILFNRVLGVSGSQNKGSTMEEELENITAKHIVSNDSSDSDDEAQGPKGTENEEAEKEYQSDNQASWVHRMLMALVSDSALFNTREGRAGKVHNFMLGLNLNTSYPLSPLRDFSSQDSFDDELDAAVADPDEFERIYEPLDVKSKKIHVVDSGLTFNLPYPLILRPQRGVDLIISFDFSARPSDTSPPFKELLLAEKWAKMNKLPFPKIDPYVFDREGLKECYVFKPKNPDVEKDCPTIIHFVLANINFRKYKAPGVLRETKEEKEIADFDIFDDPESPFSTFNFQYPNQAFKRLHDLMYFNTLNNIDVIKDAIVESIEYRRQNPSRCSVSLSNVEARKFFNKEFLSKPTV
  
Inhibitor
Name:
BDBM50085495
Synonyms:
(E)-3-(1-Benzyloxymethyl-pentadecylcarbamoyl)-acrylic acid | CHEMBL98866
Type:
Small organic molecule
Emp. Form.:
C27H43NO4
Mol. Mass.:
445.6346
SMILES:
CCCCCCCCCCCCCCC(COCc1ccccc1)NC(=O)\C=C\C(O)=O
Structure:
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