Reaction Details Report a problem with these data
Target
Phospholipase A2, membrane associated
Ligand
BDBM50085496
Substrate
n/a
Meas. Tech.
ChEBML_156195
IC50
5600±n/a nM
Citation
 Lucas, R; Ubeda, A; Payá, M; Alves, M; del Olmo, E; López, JL; San Feliciano, A Synthesis and enzyme inhibitory activities of a series of lipidic diamine and aminoalcohol derivatives on cytosolic and secretory phospholipases A2. Bioorg Med Chem Lett 10:285-8 (2000) [PubMed]  Article 
Target
Name:
Phospholipase A2, membrane associated
Synonyms:
GIIC sPLA2 | Group IIA phospholipase A2 | NPS-PLA2 | Non-Pancreatic Secretory Phospholipase A2 | Non-pancreatic secretory phospholipase A2 (hnps-PLA2) | PA2GA_HUMAN | PLA2B | PLA2G2A | PLA2L | Phosphatidylcholine 2-acylhydrolase | Phospholipase A2 group IIA | RASF-A
Type:
Hydrolase
Mol. Mass.:
16101.20
Organism:
Homo sapiens (Human)
Description:
The human nps PLA2 was cloned, and expressed in E. coli. There was a refolding process in the purification.
Residue:
144
Sequence:
MKTLLLLAVIMIFGLLQAHGNLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFARNKTTYNKKYQYYSNKHCRGSTPRC
  
Inhibitor
Name:
BDBM50085496
Synonyms:
CHEMBL89162 | N*1*,N*1*-Diethyl-hexadecane-1,2-diamine | N1,N1-diethylhexadecane-1,2-diamine
Type:
Small organic molecule
Emp. Form.:
C20H44N2
Mol. Mass.:
312.5768
SMILES:
CCCCCCCCCCCCCCC(N)CN(CC)CC
Structure:
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