Target
Endothelin-1 receptor
Ligand
BDBM50085854
Substrate
n/a
Meas. Tech.
ChEMBL_63363 (CHEMBL676099)
IC50
22±n/a nM
Citation
 Astles, PCBrown, TJHalley, FHandscombe, CMHarris, NVMajid, TNMcCarthy, CMcLay, IMMorley, APorter, BRoach, AGSargent, CSmith, CWalsh, RJ Selective ET(A) antagonists. 5. Discovery and structure-activity relationships of phenoxyphenylacetic acid derivatives. J Med Chem 43:900-10 (2000) [PubMed]  Article 
Target
Name:
Endothelin-1 receptor
Synonyms:
EDNRA_RAT | ENDOTHELIN A | Ednra | Endothelin receptor | Endothelin-1 receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
48256.91
Organism:
RAT
Description:
ENDOTHELIN A EDNRA RAT::P26684
Residue:
426
Sequence:
MGVLCFLASFWLALVGGAIADNAERYSANLSSHVEDFTPFPGTEFNFLGTTLQPPNLALPSNGSMHGYCPQQTKITTAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPLITAIEIVSIWILSFILAIPEAIGFVMVPFEYKGEQHRTCMLNATTKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCHQSKSLMTSVPMNGTSIQWKNQEQNHNTERSSHKDSMN
  
Inhibitor
Name:
BDBM50085854
Synonyms:
CHEMBL171638 | [2-Cyano-5-(thiophen-3-ylmethoxy)-phenoxy]-(2-fluoro-phenyl)-acetic acid
Type:
Small organic molecule
Emp. Form.:
C20H14FNO4S
Mol. Mass.:
383.393
SMILES:
OC(=O)C(Oc1cc(OCc2ccsc2)ccc1C#N)c1ccccc1F
Structure:
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