Target
Endothelin-1 receptor
Ligand
BDBM50085859
Substrate
n/a
Meas. Tech.
ChEMBL_63363 (CHEMBL676099)
IC50
6±n/a nM
Citation
 Astles, PCBrown, TJHalley, FHandscombe, CMHarris, NVMajid, TNMcCarthy, CMcLay, IMMorley, APorter, BRoach, AGSargent, CSmith, CWalsh, RJ Selective ET(A) antagonists. 5. Discovery and structure-activity relationships of phenoxyphenylacetic acid derivatives. J Med Chem 43:900-10 (2000) [PubMed]  Article 
Target
Name:
Endothelin-1 receptor
Synonyms:
EDNRA_RAT | ENDOTHELIN A | Ednra | Endothelin receptor | Endothelin-1 receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
48256.91
Organism:
RAT
Description:
ENDOTHELIN A EDNRA RAT::P26684
Residue:
426
Sequence:
MGVLCFLASFWLALVGGAIADNAERYSANLSSHVEDFTPFPGTEFNFLGTTLQPPNLALPSNGSMHGYCPQQTKITTAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPLITAIEIVSIWILSFILAIPEAIGFVMVPFEYKGEQHRTCMLNATTKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCHQSKSLMTSVPMNGTSIQWKNQEQNHNTERSSHKDSMN
  
Inhibitor
Name:
BDBM50085859
Synonyms:
(2-Chloro-phenyl)-[2-cyano-5-(pyridin-4-ylmethoxy)-phenoxy]-acetic acid | CHEMBL171844
Type:
Small organic molecule
Emp. Form.:
C21H15ClN2O4
Mol. Mass.:
394.808
SMILES:
OC(=O)C(Oc1cc(OCc2ccncc2)ccc1C#N)c1ccccc1Cl
Structure:
Search PDB for entries with ligand similarity: