Reaction Details Report a problem with these data
Target
Kappa-type opioid receptor
Ligand
BDBM50089153
Substrate
n/a
Meas. Tech.
ChEBML_146531
Ki
1076±n/a nM
Citation
 Thomas, JB; Atkinson, RN; Rothman, RB; Burgess, JP; Mascarella, SW; Dersch, CM; Xu, H; Carroll, FI 4-[(8-Alkyl-8-azabicyclo[3.2.1]octyl-3-yl)-3-arylanilino]-N,N-diethylbenzamides: high affinity, selective ligands for the delta opioid receptor illustrate factors important to antagonist activity. Bioorg Med Chem Lett 10:1281-4 (2000) [PubMed]  Article 
Target
Name:
Kappa-type opioid receptor
Synonyms:
Kappa Opioid Receptor | OPIATE Kappa | OPRK1 | OPRK_CAVPO | Opiate Kappa 1 | mu/kappa opioid receptor
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42744.99
Organism:
Cavia porcellus (domestic guinea pig)
Description:
P41144
Residue:
380
Sequence:
MGRRRQGPAQPASELPARNACLLPNGSAWLPGWAEPDGNGSAGPQDEQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIILGGTKVREDVDIIECSLQFPDDDYSWWDLFMKICVFVFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPIKMRMERQSTSRVRNTVQDPAYMRNVDGVNKPV
  
Inhibitor
Name:
BDBM50089153
Synonyms:
4-[(8-Allyl-8-aza-bicyclo[3.2.1]oct-3-yl)-(3-methoxy-phenyl)-amino]-N,N-diethyl-benzamide | CHEMBL3085004
Type:
Small organic molecule
Emp. Form.:
C28H37N3O2
Mol. Mass.:
447.6123
SMILES:
[H][C@]12CC[C@]([H])(C[C@@H](C1)N(c1ccc(cc1)C(=O)N(CC)CC)c1cccc(OC)c1)N2CC=C |r,TLB:9:7:31:3.2|
Structure:
Search PDB for entries with ligand similarity: