Target
Caspase-1
Ligand
BDBM50291985
Substrate
n/a
Meas. Tech.
ChEMBL_46509
KON
271000 M-1s-1
Citation
 Talanian, RVBrady, KDCryns, VL Caspases as targets for anti-inflammatory and anti-apoptotic drug discovery. J Med Chem 43:3351-71 (2000) [PubMed]  Article
Target
Name:
Caspase-1
Synonyms:
Caspase | Caspase 1 | ICE | Interleukin-1 beta convertase | Interleukin-1 beta-converting enzyme
Type:
Enzyme
Mol. Mass.:
45154.13
Organism:
Homo sapiens (Human)
Description:
P29466
Residue:
404
Sequence:
MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDSVIPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDNPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH
  
Inhibitor
Name:
BDBM50291985
Synonyms:
3-{[1-(2-Benzyloxycarbonylamino-3-methyl-butyryl)-piperidine-2-carbonyl]-amino}-4-oxo-5-(2-phenyl-5-trifluoromethyl-2H-pyrazol-3-yloxy)-pentanoic acid | CHEMBL114531
Type:
Small organic molecule
Emp. Form.:
C34H38F3N5O8
Mol. Mass.:
701.6894
SMILES:
CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)N1CCCCC1C(=O)N[C@@H](CC(O)=O)C(=O)COc1cc(nn1-c1ccccc1)C(F)(F)F
Structure:
Search PDB for entries with ligand similarity: