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Target
Coagulation factor X
Ligand
BDBM50093064
Substrate
n/a
Meas. Tech.
ChEBML_160982
IC50
46±n/a nM
Citation
 Semple, JE; Levy, OE; Minami, NK; Owens, TD; Siev, DV Novel, potent and selective chimeric FXa inhibitors featuring hydrophobic P1-ketoamide moieties. Bioorg Med Chem Lett 10:2305-9 (2001) [PubMed]  Article 
Target
Name:
Coagulation factor X
Synonyms:
Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:
Enzyme
Mol. Mass.:
54726.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK
  
Inhibitor
Name:
BDBM50093064
Synonyms:
(R)-5-Nitro-Guanidino-2-phenylmethanesulfonylamino-pentanoic acid ({(S)-2-[(benzo[1,3]dioxol-5-ylmethyl)-carbamoyl]-1-cyclohexylmethyl-2-oxo-ethylcarbamoyl}-methyl)-methyl-amide | CHEMBL75006
Type:
Small organic molecule
Emp. Form.:
C33H44N8O10S
Mol. Mass.:
744.815
SMILES:
CN(CC(=O)N[C@@H](CC1CCCCC1)C(=O)C(=O)NCc1ccc2OCOc2c1)C(=O)[C@@H](CCN=C(N)N[N+]([O-])=O)NS(=O)(=O)Cc1ccccc1 |w:34.36|
Structure:
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