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TargetCytochrome P450 17A1
LigandBDBM50409039
Substrate/Competitorn/a
Meas. Tech.ChEMBL_50374
IC50 430±n/a nM
Citation Hartmann, RWHector, MWachall, BGPalusczak, APalzer, MHuch, VVeith, M Synthesis and evaluation of 17-aliphatic heterocycle-substituted steroidal inhibitors of 17alpha-hydroxylase/C17-20-lyase (P450 17). J Med Chem43:4437-45 (2000) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cytochrome P450 17A1
Name:Cytochrome P450 17A1
Synonyms:Cytochrome P450 17,20 lyase | Cytochrome P450-C17 | Steroid 17-alpha-hydroxylase/17,20 lyase
Type:Enzyme
Mol. Mass.:57255.68
Organism:Rattus norvegicus (Rat)
Description:P11715
Residue:507
Sequence:
MWELVGLLLLILAYFFWVKSKTPGAKLPRSLPSLPLVGSLPFLPRRGHMHVNFFKLQEKY
GPIYSLRLGTTTTVIIGHYQLAREVLIKKGKEFSGRPQMVTQSLLSDQGKGVAFADAGSS
WHLHRKLVFSTFSLFKDGQKLEKLICQEAKSLCDMMLAHDKESIDLSTPIFMSVTNIICA
ICFNISYEKNDPKLTAIKTFTEGIVDATGDRNLVDIFPWLTIFPNKGLEVIKGYAKVRNE
VLTGIFEKCREKFDSQSISSLTDILIQAKMNSDNNNSCEGRDPDVFSDRHILATVGDIFG
AGIETTTTVLKWILAFLVHNPEVKKKIQKEIDQYVGFSRTPTFNDRSHLLMLEATIREVL
RIRPVAPMLIPHKANVDSSIGEFTVPKDTHVVVNLWALHHDENEWDQPDQFMPERFLDPT
GSHLITPTQSYLPFGAGPRSCIGEALARQELFVFTALLLQRFDLDVSDDKQLPRLEGDPK
VVFLIDPFKVKITVRQAWMDAQAEVST
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50409039
NameBDBM50409039
Synonyms:CHEMBL2111951
TypeSmall organic molecule
Emp. Form.C21H31NO
Mol. Mass.313.4769
SMILESC[C@]12CC[C@H]3[C@@H](CC=C4C[C@@H](O)CC[C@]34C)C1=CC[C@@H]2[C@H]1CN1 |r,c:19,t:7|
Structure
n/a