Target
Complement factor B
Ligand
BDBM50540313
Substrate
n/a
Meas. Tech.
ChEMBL_1981492 (CHEMBL4614754)
IC50
120±n/a nM
Citation
 Mainolfi, NEhara, TKarki, RGAnderson, KMac Sweeney, ALiao, SMArgikar, UAJendza, KZhang, CPowers, JKlosowski, DWCrowley, MKawanami, TDing, JApril, MForster, CSerrano-Wu, MCapparelli, MRamqaj, RSolovay, CCumin, FSmith, TMFerrara, LLee, WLong, DPrentiss, MDe Erkenez, AYang, LLiu, FSellner, HSirockin, FValeur, EErbel, POstermeier, DRamage, PGerhartz, BSchubart, AFlohr, SGradoux, NFeifel, RVogg, BWiesmann, CMaibaum, JEder, JSedrani, RHarrison, RAMogi, MJaffee, BDAdams, CM Discovery of 4-((2 S,4 S)-4-Ethoxy-1-((5-methoxy-7-methyl-1 H-indol-4-yl)methyl)piperidin-2-yl)benzoic Acid (LNP023), a Factor B Inhibitor Specifically Designed To Be Applicable to Treating a Diverse Array of Complement Mediated Diseases J Med Chem 63:5697-5722 (2020) [PubMed]  Article 
Target
Name:
Complement factor B
Synonyms:
3.4.21.47 | Bf | C3/C5 convertase | CFAB_MOUSE | Cfb | Complement factor B | Complement factor B Ba fragment | Complement factor B Bb fragment | H2-Bf
Type:
PROTEIN
Mol. Mass.:
85011.61
Organism:
Mus musculus
Description:
ChEMBL_119901
Residue:
761
Sequence:
MESPQLCLVLLVLGFSSGGVSATPVLEARPQVSCSLEGVEIKGGSFQLLQGGQALEYLCPSGFYPYPVQTRTCRSTGSWSDLQTRDQKIVQKAECRAIRCPRPQDFENGEFWPRSPFYNLSDQISFQCYDGYVLRGSANRTCQENGRWDGQTAICDDGAGYCPNPGIPIGTRKVGSQYRLEDIVTYHCSRGLVLRGSQKRKCQEGGSWSGTEPSCQDSFMYDSPQEVAEAFLSSLTETIEGADAEDGHSPGEQQKRKIVLDPSGSMNIYLVLDGSDSIGSSNFTGAKRCLTNLIEKVASYGVRPRYGLLTYATVPKVLVRVSDERSSDADWVTEKLNQISYEDHKLKSGTNTKRALQAVYSMMSWAGDAPPEGWNRTRHVIIIMTDGLHNMGGNPVTVIQDIRALLDIGRDPKNPREDYLDVYVFGVGPLVDSVNINALASKKDNEHHVFKVKDMEDLENVFYQMIDETKSLSLCGMVWEHKKGNDYHKQPWQAKISVTRPLKGHETCMGAVVSEYFVLTAAHCFMVDDQKHSIKVSVGGQRRDLEIEEVLFHPKYNINGKKAEGIPEFYDYDVALVKLKNKLKYGQTLRPICLPCTEGTTRALRLPQTATCKQHKEQLLPVKDVKALFVSEQGKSLTRKEVYIKNGDKKASCERDATKAQGYEKVKDASEVVTPRFLCTGGVDPYADPNTCKGDSGGPLIVHKRSRFIQVGVISWGVVDVCRDQRRQQLVPSYARDFHINLFQVLPWLKDKLKDEDLGFL
  
Inhibitor
Name:
BDBM50540313
Synonyms:
CHEMBL4644208
Type:
Small organic molecule
Emp. Form.:
C25H30N2O3
Mol. Mass.:
406.5173
SMILES:
CCO[C@H]1CCN(Cc2c(C)cc(C)c3[nH]ccc23)[C@@H](C1)c1ccc(cc1)C(O)=O |r|
Structure:
Search PDB for entries with ligand similarity: