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Target
Urokinase-type plasminogen activator
Ligand
BDBM50098139
Substrate
n/a
Meas. Tech.
ChEBML_213156
Ki
160±n/a nM
Citation
 Wilson, KJ; Illig, CR; Subasinghe, N; Hoffman, JB; Rudolph, MJ; Soll, R; Molloy, CJ; Bone, R; Green, D; Randall, T; Zhang, M; Lewandowski, FA; Zhou, Z; Sharp, C; Maguire, D; Grasberger, B; DesJarlais, RL; Spurlino, J Synthesis of thiophene-2-carboxamidines containing 2-aminothiazoles and their biological evaluation as urokinase inhibitors. Bioorg Med Chem Lett 11:915-8 (2001) [PubMed]  Article 
Target
Name:
Urokinase-type plasminogen activator
Synonyms:
PLAU | U-plasminogen activator | UROK_HUMAN | Urokinase | Urokinase-type plasminogen activator (uPA) | Urokinase-type plasminogen activator/surface receptor
Type:
Enzyme
Mol. Mass.:
48528.62
Organism:
Homo sapiens (Human)
Description:
P00749
Residue:
431
Sequence:
MRALLARLLLCVLVVSDSKGSNELHQVPSNCDCLNGGTCVSNKYFSNIHWCNCPKKFGGQHCEIDKSKTCYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLGKHNYCRNPDNRRRPWCYVQVGLKPLVQECMVHDCADGKKPSSPPEELKFQCGQKTLRPRFKIIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFIDYPKKEDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQTICLPSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIRSHTKEENGLAL
  
Inhibitor
Name:
BDBM50098139
Synonyms:
5-Methylsulfanyl-4-[2-(3,4,5-trimethoxy-phenylamino)-thiazol-4-yl]-thiophene-2-carboxamidine | CHEMBL353478
Type:
Small organic molecule
Emp. Form.:
C18H20N4O3S3
Mol. Mass.:
436.571
SMILES:
COc1cc(Nc2nc(cs2)-c2cc(sc2SC)C(N)=N)cc(OC)c1OC
Structure:
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