Reaction Details
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N-alpha-acetyltransferase 50
Ligand
BDBM50541855
Substrate
n/a
Meas. Tech.
ChEMBL_1985503 (CHEMBL4618909)
IC50
13±n/a nM
Citation
Kung, PP; Bingham, P; Burke, BJ; Chen, Q; Cheng, X; Deng, YL; Dou, D; Feng, J; Gallego, GM; Gehring, MR; Grant, SK; Greasley, S; Harris, AR; Maegley, KA; Meier, J; Meng, X; Montano, JL; Morgan, BA; Naughton, BS; Palde, PB; Paul, TA; Richardson, P; Sakata, S; Shaginian, A; Sonnenburg, WK; Subramanyam, C; Timofeevski, S; Wan, J; Yan, W; Stewart, AE Characterization of Specific ACS Med Chem Lett 11:1175-1184 (2020) [PubMed] Article More Info.:
Target
Name:
N-alpha-acetyltransferase 50
Synonyms:
2.3.1.- | 2.3.1.258 | MAK3 | N-acetyltransferase 13 | N-acetyltransferase 5 | N-acetyltransferase san homolog | N-alpha-acetyltransferase 50 | N-epsilon-acetyltransferase 50 | NAA50 | NAA50_HUMAN | NAT13 | NAT5 | NatE catalytic subunit | Synonyms=MAK3 | hNAT5 | hNaa50p | hSAN
Type:
PROTEIN
Mol. Mass.:
19405.69
Organism:
Homo sapiens
Description:
ChEMBL_119947
Residue:
169
Sequence:
MKGSRIELGDVTPHNIKQLKRLNQVIFPVSYNDKFYKDVLEVGELAKLAYFNDIAVGAVCCRVDHSQNQKRLYIMTLGCLAPYRRLGIGTKMLNHVLNICEKDGTFDNIYLHVQISNESAIDFYRKFGFEIIETKKNYYKRIEPADAHVLQKNLKVPSGQNADVQKTDN
Inhibitor
Name:
BDBM50541855
Synonyms:
CHEMBL4642788
Type:
Small organic molecule
Emp. Form.:
C23H24N10O5S
Mol. Mass.:
552.566
SMILES:
CNC(=O)c1csc(n1)C1C[C@@H](CN1C(=O)c1ccc(cc1)-c1nn[nH]n1)NC(=O)[C@@H]1CC(=O)N(C)C(=O)N1 |r|
Structure:
