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Target
Interleukin-1 receptor type 1
Ligand
BDBM50543142
Substrate
n/a
Meas. Tech.
ChEMBL_1988718 (CHEMBL4622265)
IC50
>6500±n/a nM
Citation
 Knoepfel, T; Nimsgern, P; Jacquier, S; Bourrel, M; Vangrevelinghe, E; Glatthar, R; Behnke, D; Alper, PB; Michellys, PY; Deane, J; Junt, T; Zipfel, G; Limonta, S; Hawtin, S; Andre, C; Boulay, T; Loetscher, P; Faller, M; Blank, J; Feifel, R; Betschart, C Target-Based Identification and Optimization of 5-Indazol-5-yl Pyridones as Toll-like Receptor 7 and 8 Antagonists Using a Biochemical TLR8 Antagonist Competition Assay. J Med Chem 63:8276-8295 (2020) [PubMed]  Article 
Target
Name:
Interleukin-1 receptor type 1
Synonyms:
CD121 antigen-like family member A | CD_antigen=CD121a | IL-1R-1 | IL-1R-alpha | IL-1RT-1 | IL-1RT1 | IL1R | IL1R1 | IL1R1_HUMAN | IL1RA | IL1RT1 | Interleukin-1 receptor alpha | Interleukin-1 receptor type 1 | Interleukin-1 receptor type 1, membrane form | Interleukin-1 receptor type 1, soluble form | Interleukin-1 receptor type I | mIL-1R1 | mIL-1RI | p80 | sIL-1R1 | sIL-1RI
Type:
PROTEIN
Mol. Mass.:
65411.77
Organism:
Homo sapiens
Description:
ChEMBL_198
Residue:
569
Sequence:
MKVLLRLICFIALLISSLEADKCKEREEKIILVSSANEIDVRPCPLNPNEHKGTITWYKDDSKTPVSTEQASRIHQHKEKLWFVPAKVEDSGHYYCVVRNSSYCLRIKISAKFVENEPNLCYNAQAIFKQKLPVAGDGGLVCPYMEFFKNENNELPKLQWYKDCKPLLLDNIHFSGVKDRLIVMNVAEKHRGNYTCHASYTYLGKQYPITRVIEFITLEENKPTRPVIVSPANETMEVDLGSQIQLICNVTGQLSDIAYWKWNGSVIDEDDPVLGEDYYSVENPANKRRSTLITVLNISEIESRFYKHPFTCFAKNTHGIDAAYIQLIYPVTNFQKHMIGICVTLTVIIVCSVFIYKIFKIDIVLWYRDSCYDFLPIKASDGKTYDAYILYPKTVGEGSTSDCDIFVFKVLPEVLEKQCGYKLFIYGRDDYVGEDIVEVINENVKKSRRLIIILVRETSGFSWLGGSSEEQIAMYNALVQDGIKVVLLELEKIQDYEKMPESIKFIKQKHGAIRWSGDFTQGPQSAKTRFWKNVRYHMPVQRRSPSSKHQLLSPATKEKLQREAHVPLG
  
Inhibitor
Name:
BDBM50543142
Synonyms:
CHEMBL4641633
Type:
Small organic molecule
Emp. Form.:
C21H20F4N4O
Mol. Mass.:
420.4033
SMILES:
F[C@H]1CNCC[C@@H]1n1cc2cc(cc(c2n1)C(F)(F)F)-c1ccc(=O)n2CCCc12 |r|
Structure:
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