Target
Adenosine kinase
Ligand
BDBM50095372
Substrate
n/a
Meas. Tech.
ChEMBL_31125 (CHEMBL643553)
IC50
8.3±n/a nM
Citation
 Lee, CHJiang, MCowart, MGfesser, GPerner, RKim, KHGu, YGWilliams, MJarvis, MFKowaluk, EAStewart, AOBhagwat, SS Discovery of 4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin-3-yl)pyrido[2,3-d]pyrimidine, an orally active, non-nucleoside adenosine kinase inhibitor.. J Med Chem 44:2133-8 (2001) [PubMed]  Article 
Target
Name:
Adenosine kinase
Synonyms:
ADENOSINE | ADK_RAT | Adenosine 5-phosphotransferase | Adenosine Kinase (AK) | Adenosine kinase | Adk
Type:
Enzyme
Mol. Mass.:
40130.14
Organism:
Rattus norvegicus (rat)
Description:
Rat brain cytosol as enzyme source.
Residue:
361
Sequence:
MAAADEPKPKKLKVEAPEALSENVLFGMGNPLLDISAVVDKDFLDKYSLKPNDQILAEDKHKELFDELVKKFKVEYHAGGSTQNSMKVAQWMIQEPHRAATFFGCIGIDKFGEILKSKAADAHVDAHYYEQNEQPTGTCAACITGGNRSLVANLAAANCYKKEKHLDLENNWMLVEKARVYYIAGFFLTVSPESVLKVARYAAENNRTFTLNLSAPFISQFFKEALMEVMPYVDILFGNETEAATFAREQGFETKDIKEIARKTQALPKVNSKRQRTVIFTQGRDDTIVATGNDVTAFPVLDQNQEEIVDTNGAGDAFVGGFLSQLVSNKPLTECIRAGHYAASVIIRRTGCTFPEKPDFH
  
Inhibitor
Name:
BDBM50095372
Synonyms:
5-Cyclohexyl-7-(4-dimethylamino-phenyl)-pyrido[2,3-d]pyrimidin-4-ylamine | CHEMBL302921
Type:
Small organic molecule
Emp. Form.:
C21H25N5
Mol. Mass.:
347.4567
SMILES:
CN(C)c1ccc(cc1)-c1cc(C2CCCCC2)c2c(N)ncnc2n1
Structure:
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