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Target
Dual specificity protein phosphatase 3
Ligand
BDBM50106494
Substrate
n/a
Meas. Tech.
ChEMBL_214523 (CHEMBL819515)
IC50
>10000±n/a nM
Citation
 Lazo, JS; Aslan, DC; Southwick, EC; Cooley, KA; Ducruet, AP; Joo, B; Vogt, A; Wipf, P Discovery and biological evaluation of a new family of potent inhibitors of the dual specificity protein phosphatase Cdc25. J Med Chem 44:4042-9 (2001) [PubMed]  Article 
Target
Name:
Dual specificity protein phosphatase 3
Synonyms:
DUS3_HUMAN | DUSP3 | Dual specificity protein phosphatase (VHR) | Dual specificity protein phosphatase 3 | Dual specificity protein phosphatase VHR | Protein Tyrosine Phosphatase VHR | Tyrosine-protein phosphatase non-receptor type 1 | VHR
Type:
Hydrolase
Mol. Mass.:
20480.58
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
185
Sequence:
MSGSFELSVQDLNDLLSDGSGCYSLPSQPCNEVTPRIYVGNASVAQDIPKLQKLGITHVLNAAEGRSFMHVNTNANFYKDSGITYLGIKANDTQEFNLSAYFERAADFIDQALAQKNGRVLVHCREGYSRSPTLVIAYLMMRQKMDVKSALSIVRQNREIGPNDGFLAQLCQLNDRLAKEGKLKP
  
Inhibitor
Name:
BDBM50106494
Synonyms:
7-Chloro-6-(2-morpholin-4-yl-ethylamino)-quinoline-5,8-dione | CHEMBL337520
Type:
Small organic molecule
Emp. Form.:
C15H16ClN3O3
Mol. Mass.:
321.759
SMILES:
Oc1c(Cl)c(N=CCN2CCOCC2)c(O)c2cccnc12 |w:6.6|
Structure:
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