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Target
Apolipoprotein L1
Ligand
BDBM50547876
Substrate
n/a
Meas. Tech.
ChEMBL_2019383 (CHEMBL4672961)
IC50
<250±n/a nM
Citation
 Sabnis, RW Novel APOL1 Inhibitors for Treating Kidney Diseases. ACS Med Chem Lett 11:2352-2353 (2020) [PubMed]  Article 
Target
Name:
Apolipoprotein L1
Synonyms:
APOL | APOL1 | APOL1_HUMAN | Apo-L | ApoL-I | Apolipoprotein L | Apolipoprotein L-I | Apolipoprotein L1
Type:
PROTEIN
Mol. Mass.:
43969.63
Organism:
Homo sapiens
Description:
ChEMBL_120089
Residue:
398
Sequence:
MEGAALLRVSVLCIWMSALFLGVGVRAEEAGARVQQNVPSGTDTGDPQSKPLGDWAAGTMDPESSIFIEDAIKYFKEKVSTQNLLLLLTDNEAWNGFVAAAELPRNEADELRKALDNLARQMIMKDKNWHDKGQQYRNWFLKEFPRLKSELEDNIRRLRALADGVQKVHKGTTIANVVSGSLSISSGILTLVGMGLAPFTEGGSLVLLEPGMELGITAALTGITSSTMDYGKKWWTQAQAHDLVIKSLDKLKEVREFLGENISNFLSLAGNTYQLTRGIGKDIRALRRARANLQSVPHASASRPRVTEPISAESGEQVERVNEPSILEMSRGVKLTDVAPVSFFLVLDVVYLVYESKHLHEGAKSETAEELKKVAQELEEKLNILNNNYKILQADQEL
  
Inhibitor
Name:
BDBM50547876
Synonyms:
CHEMBL4791770 | US20230271945, Compound 20
Type:
Small organic molecule
Emp. Form.:
C22H18F2N4O2
Mol. Mass.:
408.4007
SMILES:
Fc1cc(F)c2[nH]c(c(CCC(=O)N[C@H]3CCNC3=O)c2c1)-c1ccc(cc1)C#N |r|
Structure:
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