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Target
Ghrelin O-acyltransferase
Ligand
BDBM50548069
Substrate
n/a
Meas. Tech.
ChEMBL_2019857 (CHEMBL4673670)
IC50
30±n/a nM
Citation
 Iyer, MR; Wood, CM; Kunos, G Recent progress in the discovery of ghrelin  RSC Med Chem 11:1136-1144 (2020) [PubMed]  Article 
Target
Name:
Ghrelin O-acyltransferase
Synonyms:
2.3.1.- | Ghrelin O-acyltransferase | Gm171 | Goat | MBOA4_MOUSE | Mboat4 | Membrane-bound O-acyltransferase domain-containing protein 4 | O-acyltransferase domain-containing protein 4
Type:
PROTEIN
Mol. Mass.:
49896.50
Organism:
Mus musculus
Description:
ChEMBL_103545
Residue:
435
Sequence:
MDWLQLFFLHPLSFYQGAAFPFALLFNYLCILDTFSTRARYLFLLAGGGVLAFAAMGPYSLLIFIPALCAVALVSFLSPQEVHRLTFFFQMGWQTLCHLGLHYTEYYLGEPPPVRFYITLSSLMLLTQRVTSLSLDICEGKVEAPRRGIRSKSSFSEHLWDALPHFSYLLFFPALLGGSLCSFRRFQACVQRSSSLYPSISFRALTWRGLQILGLECLKVALRSAVSAGAGLDDCQRLECIYLMWSTAWLFKLTYYSHWILDDSLLHAAGFGAEAGQGPGEEGYVPDVDIWTLETTHRISLFARQWNRSTALWLRRLVFRKSRRWPLLQTFAFSAWWHGLHPGQVFGFLCWSVMVKADYLIHTFANVCIRSWPLRLLYRALTWAHTQLIIAYIMLAVEGRSLSSLCQLCCSYNSLFPVMYGLLLFLLAERKDKRN
  
Inhibitor
Name:
BDBM50548069
Synonyms:
CHEMBL4741670
Type:
Small organic molecule
Emp. Form.:
C23H42N4O2S
Mol. Mass.:
438.67
SMILES:
CCCC[C@H]1C[C@@H](C1)C(=O)NC[C@H]1CCCN1C(=O)[C@@H](NC(=S)CNC)C(C)(C)C |r,wU:12.12,6.8,wD:19.27,4.3,(17.81,-5.97,;17.5,-7.47,;18.64,-8.5,;20.11,-8.02,;21.25,-9.05,;21.33,-10.59,;22.86,-10.5,;22.79,-8.97,;24.01,-11.53,;25.48,-11.05,;23.69,-13.04,;24.84,-14.07,;24.52,-15.57,;25.55,-16.72,;24.78,-18.05,;23.28,-17.73,;23.11,-16.21,;21.77,-15.44,;21.77,-13.9,;20.44,-16.21,;19.11,-15.44,;17.77,-16.21,;17.77,-17.75,;16.44,-15.44,;15.1,-16.21,;13.77,-15.44,;20.44,-17.75,;19.11,-18.52,;21.77,-18.52,;20.42,-19.28,)|
Structure:
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