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Target
Cystathionine gamma-lyase
Ligand
BDBM50548267
Substrate
n/a
Meas. Tech.
ChEMBL_2021492 (CHEMBL4675305)
IC50
6200±n/a nM
Citation
 Hu, Y; Wang, L; Han, X; Zhou, Y; Zhang, T; Wang, L; Hong, T; Zhang, W; Guo, XX; Sun, J; Qi, Y; Yu, J; Liu, H; Wu, F Discovery of a Bioactive Inhibitor with a New Scaffold for Cystathionine ?-Lyase. J Med Chem 62:1677-1683 (2019) [PubMed]  Article 
Target
Name:
Cystathionine gamma-lyase
Synonyms:
CGL_HUMAN | CTH | Cystathionine gamma-lyase (CSE) | Cysteine-protein sulfhydrase | Gamma-cystathionase
Type:
Protein
Mol. Mass.:
44509.52
Organism:
Homo sapiens (Human)
Description:
P32929
Residue:
405
Sequence:
MQEKDASSQGFLPHFQHFATQAIHVGQDPEQWTSRAVVPPISLSTTFKQGAPGQHSGFEYSRSGNPTRNCLEKAVAALDGAKYCLAFASGLAATVTITHLLKAGDQIICMDDVYGGTNRYFRQVASEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNPTQKVIDIEGCAHIVHKHGDIILVVDNTFMSPYFQRPLALGADISMYSATKYMNGHSDVVMGLVSVNCESLHNRLRFLQNSLGAVPSPIDCYLCNRGLKTLHVRMEKHFKNGMAVAQFLESNPWVEKVIYPGLPSHPQHELVKRQCTGCTGMVTFYIKGTLQHAEIFLKNLKLFTLAESLGGFESLAELPAIMTHASVLKNDRDVLGISDTLIRLSVGLEDEEDLLEDLDQALKAAHPPSGSHS
  
Inhibitor
Name:
BDBM50548267
Synonyms:
CHEMBL4761159
Type:
Small organic molecule
Emp. Form.:
C17H16O6
Mol. Mass.:
316.3053
SMILES:
COc1cccc2C(=O)C3=C([C@H](C)O[C@@H](CC(O)=O)C3)C(=O)c12 |r,t:9|
Structure:
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