Reaction Details Report a problem with these data
Target
Glucagon receptor
Ligand
BDBM50110066
Substrate
n/a
Meas. Tech.
ChEBML_72874
IC50
58±n/a nM
Citation
 Ling, A; Plewe, M; Gonzalez, J; Madsen, P; Sams, CK; Lau, J; Gregor, V; Murphy, D; Teston, K; Kuki, A; Shi, S; Truesdale, L; Kiel, D; May, J; Lakis, J; Anderes, K; Iatsimirskaia, E; Sidelmann, UG; Knudsen, LB; Brand, CL; Polinsky, A Human glucagon receptor antagonists based on alkylidene hydrazides. Bioorg Med Chem Lett 12:663-6 (2002) [PubMed]  Article 
Target
Name:
Glucagon receptor
Synonyms:
GCGR | GL-R | GLR_HUMAN | Glucagon Receptor (GCGR) | Glucagon receptor (GlucR)
Type:
Enzyme
Mol. Mass.:
54026.92
Organism:
Homo sapiens (Human)
Description:
P47871
Residue:
477
Sequence:
MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
  
Inhibitor
Name:
BDBM50110066
Synonyms:
3-Chloro-4-hydroxy-benzoic acid [1-[4-(4-trifluoromethoxy-benzyloxy)-naphthalen-1-yl]-meth-(E)-ylidene]-hydrazide | 3-Chloro-4-hydroxy-benzoic acid [4-(4-trifluoromethoxy-benzyloxy)-naphthalen-1-ylmethylene]-hydrazide | CHEMBL346226
Type:
Small organic molecule
Emp. Form.:
C26H18ClF3N2O4
Mol. Mass.:
514.88
SMILES:
Oc1ccc(cc1Cl)C(=O)N\N=C\c1ccc(OCc2ccc(OC(F)(F)F)cc2)c2ccccc12
Structure:
Search PDB for entries with ligand similarity: