Reaction Details Report a problem with these data
Target
Serine protease 1
Ligand
BDBM50112519
Substrate
n/a
Meas. Tech.
ChEBML_213077
Ki
15±n/a nM
Citation
 Shaw, KJ; Guilford, WJ; Griedel, BD; Sakata, S; Trinh, L; Wu, S; Xu, W; Zhao, Z; Morrissey, MM Benzimidazole-based fXa inhibitors with improved thrombin and trypsin selectivity. Bioorg Med Chem Lett 12:1311-4 (2002) [PubMed]  Article 
Target
Name:
Serine protease 1
Synonyms:
Alpha-trypsin chain 1 | Alpha-trypsin chain 2 | Beta-trypsin | Cationic trypsinogen | PRSS1 | Serine protease 1 | TRP1 | TRY1 | TRY1_HUMAN | TRYP1 | Thrombin & trypsin | Trypsin | Trypsin I | Trypsin-1
Type:
Enzyme
Mol. Mass.:
26557.80
Organism:
Homo sapiens (Human)
Description:
P07477
Residue:
247
Sequence:
MNPLLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLNSGYHFCGGSLINEQWVVSAGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVINARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKITSNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGDGCAQKNKPGVYTKVYNYVKWIKNTIAANS
  
Inhibitor
Name:
BDBM50112519
Synonyms:
({1-(7-Carbamimidoyl-naphthalen-2-ylmethyl)-2-ethyl-5-[1-(1-imino-ethyl)-piperidin-4-yloxy]-1H-benzoimidazol-4-yl}-carboxymethyl-amino)-acetic acid | CHEMBL281591
Type:
Small organic molecule
Emp. Form.:
C32H37N7O5
Mol. Mass.:
599.6801
SMILES:
CCc1nc2c(N(CC(O)=O)CC(O)=O)c(OC3CCN(CC3)C(C)=N)ccc2n1Cc1ccc2ccc(cc2c1)C(N)=N
Structure:
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