Reaction Details Report a problem with these data
Target
Serine protease 1
Ligand
BDBM50112510
Substrate
n/a
Meas. Tech.
ChEBML_213077
Ki
140±n/a nM
Citation
 Shaw, KJ; Guilford, WJ; Griedel, BD; Sakata, S; Trinh, L; Wu, S; Xu, W; Zhao, Z; Morrissey, MM Benzimidazole-based fXa inhibitors with improved thrombin and trypsin selectivity. Bioorg Med Chem Lett 12:1311-4 (2002) [PubMed]  Article 
Target
Name:
Serine protease 1
Synonyms:
Alpha-trypsin chain 1 | Alpha-trypsin chain 2 | Beta-trypsin | Cationic trypsinogen | PRSS1 | Serine protease 1 | TRP1 | TRY1 | TRY1_HUMAN | TRYP1 | Thrombin & trypsin | Trypsin | Trypsin I | Trypsin-1
Type:
Enzyme
Mol. Mass.:
26557.80
Organism:
Homo sapiens (Human)
Description:
P07477
Residue:
247
Sequence:
MNPLLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLNSGYHFCGGSLINEQWVVSAGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVINARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKITSNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGDGCAQKNKPGVYTKVYNYVKWIKNTIAANS
  
Inhibitor
Name:
BDBM50112510
Synonyms:
4'-{2-Ethyl-5-[1-(1-imino-ethyl)-piperidin-4-yloxy]-benzoimidazol-1-ylmethyl}-biphenyl-3-carboxamidine | CHEMBL283901
Type:
Small organic molecule
Emp. Form.:
C30H34N6O
Mol. Mass.:
494.6306
SMILES:
CCc1nc2cc(OC3CCN(CC3)C(C)=N)ccc2n1Cc1ccc(cc1)-c1cccc(c1)C(N)=N
Structure:
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