Target
Inosine-5'-monophosphate dehydrogenase 2
Ligand
BDBM50112567
Substrate
n/a
Meas. Tech.
ChEBML_89804
IC50
>10000±n/a nM
Citation
 Gu, HHIwanowicz, EJGuo, JWatterson, SHShen, ZPitts, WJDhar, TGFleener, CARouleau, KSherbina, NZWitmer, MTredup, JHollenbaugh, D Novel diamide-based inhibitors of IMPDH. Bioorg Med Chem Lett 12:1323-6 (2002) [PubMed]  Article 
Target
Name:
Inosine-5'-monophosphate dehydrogenase 2
Synonyms:
IMDH2_HUMAN | IMP dehydrogenase 2 | IMPD 2 | IMPD2 | IMPDH-II | IMPDH2 | Inosine 5'-monophosphate dehydrogenase II (IMPDH II) | Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2) | Inosine-5 -monophosphate dehydrogenase 2 | Inosine-5'-monophosphate dehydrogenase (IMPDH)
Type:
Enzyme
Mol. Mass.:
55806.87
Organism:
Homo sapiens (Human)
Description:
Recombinant IMPDH2 expressed in E. coli.
Residue:
514
Sequence:
MADYLISGGTSYVPDDGLTAQQLFNCGDGLTYNDFLILPGYIDFTADQVDLTSALTKKITLKTPLVSSPMDTVTEAGMAIAMALTGGIGFIHHNCTPEFQANEVRKVKKYEQGFITDPVVLSPKDRVRDVFEAKARHGFCGIPITDTGRMGSRLVGIISSRDIDFLKEEEHDCFLEEIMTKREDLVVAPAGITLKEANEILQRSKKGKLPIVNEDDELVAIIARTDLKKNRDYPLASKDAKKQLLCGAAIGTHEDDKYRLDLLAQAGVDVVVLDSSQGNSIFQINMIKYIKDKYPNLQVIGGNVVTAAQAKNLIDAGVDALRVGMGSGSICITQEVLACGRPQATAVYKVSEYARRFGVPVIADGGIQNVGHIAKALALGASTVMMGSLLAATTEAPGEYFFSDGIRLKKYRGMGSLDAMDKHLSSQNRYFSEADKIKVAQGVSGAVQDKGSIHKFVPYLIAGIQHSCQDIGAKSLTQVRAMMYSGELKFEKRTSSAQVEGGVHSLHSYEKRLF
  
Inhibitor
Name:
BDBM50112567
Synonyms:
CHEMBL25087 | N-tert-Butyl-N'-(3-methoxy-4-oxazol-5-yl-phenyl)-N-methyl-oxalamide
Type:
Small organic molecule
Emp. Form.:
C17H21N3O4
Mol. Mass.:
331.3663
SMILES:
COc1cc(NC(=O)C(=O)N(C)C(C)(C)C)ccc1-c1cnco1
Structure:
Search PDB for entries with ligand similarity: