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Target
Urokinase-type plasminogen activator
Ligand
BDBM50115857
Substrate
n/a
Meas. Tech.
ChEBML_213307
Ki
250±n/a nM
Citation
 Mackman, RL; Hui, HC; Breitenbucher, JG; Katz, BA; Luong, C; Martelli, A; McGee, D; Radika, K; Sendzik, M; Spencer, JR; Sprengeler, PA; Tario, J; Verner, E; Wang, J 2-(2-Hydroxy-3-alkoxyphenyl)-1H-benzimidazole-5-carboxamidine derivatives as potent and selective urokinase-type plasminogen activator inhibitors. Bioorg Med Chem Lett 12:2019-22 (2002) [PubMed]  Article 
Target
Name:
Urokinase-type plasminogen activator
Synonyms:
PLAU | U-plasminogen activator | UROK_HUMAN | Urokinase | Urokinase-type plasminogen activator (uPA) | Urokinase-type plasminogen activator/surface receptor
Type:
Enzyme
Mol. Mass.:
48528.62
Organism:
Homo sapiens (Human)
Description:
P00749
Residue:
431
Sequence:
MRALLARLLLCVLVVSDSKGSNELHQVPSNCDCLNGGTCVSNKYFSNIHWCNCPKKFGGQHCEIDKSKTCYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLGKHNYCRNPDNRRRPWCYVQVGLKPLVQECMVHDCADGKKPSSPPEELKFQCGQKTLRPRFKIIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFIDYPKKEDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQTICLPSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIRSHTKEENGLAL
  
Inhibitor
Name:
BDBM50115857
Synonyms:
2-(2-Hydroxy-3-isobutoxy-phenyl)-1H-benzoimidazole-5-carboxamidine | 2-{5-[AMINO(IMINIO)METHYL]-1H-BENZIMIDAZOL-2-YL}-6-ISOBUTOXYBENZENOLATE | CHEMBL64676
Type:
Small organic molecule
Emp. Form.:
C18H20N4O2
Mol. Mass.:
324.377
SMILES:
CC(C)COc1cccc(-c2nc3ccc(cc3[nH]2)C(N)=N)c1O
Structure:
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