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Target
Golgi-associated PDZ and coiled-coil motif-containing protein
Ligand
BDBM50555246
Substrate
n/a
Meas. Tech.
ChEMBL_2051632 (CHEMBL4706331)
IC50
680±n/a nM
Citation
 Dougherty, PG; Wellmerling, JH; Koley, A; Lukowski, JK; Hummon, AB; Cormet-Boyaka, E; Pei, D Cyclic Peptidyl Inhibitors against CAL/CFTR Interaction for Treatment of Cystic Fibrosis. J Med Chem 63:15773-15784 (2020) [PubMed]  Article 
Target
Name:
Golgi-associated PDZ and coiled-coil motif-containing protein
Synonyms:
CAL | CFTR-associated ligand | FIG | Fused in glioblastoma | GOPC | GOPC_HUMAN | Golgi-associated PDZ and coiled-coil motif-containing protein | PDZ protein interacting specifically with TC10 | PIST
Type:
PROTEIN
Mol. Mass.:
50511.32
Organism:
Homo sapiens
Description:
ChEMBL_117103
Residue:
462
Sequence:
MSAGGPCPAAAGGGPGGASCSVGAPGGVSMFRWLEVLEKEFDKAFVDVDLLLGEIDPDQADITYEGRQKMTSLSSCFAQLCHKAQSVSQINHKLEAQLVDLKSELTETQAEKVVLEKEVHDQLLQLHSIQLQLHAKTGQSADSGTIKAKLSGPSVEELERELEANKKEKMKEAQLEAEVKLLRKENEALRRHIAVLQAEVYGARLAAKYLDKELAGRVQQIQLLGRDMKGPAHDKLWNQLEAEIHLHRHKTVIRACRGRNDLKRPMQAPPGHDQDSLKKSQGVGPIRKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILSQQRGEIEFEVVYVAPEVDSDDENVEYEDESGHRYRLYLDELEGGGNPGASCKDTSGEIKVLQGFNKKAVTDTHENGDLGTASETPLDDGASKLDDLHTLYHKKSY
  
Inhibitor
Name:
BDBM50555246
Synonyms:
CHEMBL4790861
Type:
Small organic molecule
Emp. Form.:
C69H111N25O15S2
Mol. Mass.:
1594.908
SMILES:
C[C@@H](O)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CS)NC(C)=O)C(C)(C)S)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(O)=O)C(C)(C)C |r|
Structure:
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