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TargetInosine Monophosphate Dehydrogenase Type 2 (IMPDH2)
LigandBDBM50116137
Substrate/Competitorn/a
Meas. Tech.ChEBML_89931
IC50 130±n/a nM
Citation Pitts, WJGuo, JDhar, TGShen, ZGu, HHWatterson, SHBednarz, MSChen, BCBarrish, JCBassolino, DCheney, DFleener, CARouleau, KAHollenbaugh, DLIwanowicz, EJ Rapid synthesis of triazine inhibitors of inosine monophosphate dehydrogenase. Bioorg Med Chem Lett12:2137-40 (2002) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2)
Name:Inosine-5'-monophosphate dehydrogenase (IMPDH)
Synonyms:IMP dehydrogenase 2 | IMPD 2 | IMPDH-II | Inosine 5'-monophosphate dehydrogenase II (IMPDH II) | Inosine-5 -monophosphate dehydrogenase 2 | Inosine-5''''-monophosphate dehydrogenase 2
Type:Enzyme
Mol. Mass.:55806.87
Organism:Homo sapiens (Human)
Description:Recombinant IMPDH2 expressed in E. coli.
Residue:514
Sequence:
MADYLISGGTSYVPDDGLTAQQLFNCGDGLTYNDFLILPGYIDFTADQVDLTSALTKKIT
LKTPLVSSPMDTVTEAGMAIAMALTGGIGFIHHNCTPEFQANEVRKVKKYEQGFITDPVV
LSPKDRVRDVFEAKARHGFCGIPITDTGRMGSRLVGIISSRDIDFLKEEEHDCFLEEIMT
KREDLVVAPAGITLKEANEILQRSKKGKLPIVNEDDELVAIIARTDLKKNRDYPLASKDA
KKQLLCGAAIGTHEDDKYRLDLLAQAGVDVVVLDSSQGNSIFQINMIKYIKDKYPNLQVI
GGNVVTAAQAKNLIDAGVDALRVGMGSGSICITQEVLACGRPQATAVYKVSEYARRFGVP
VIADGGIQNVGHIAKALALGASTVMMGSLLAATTEAPGEYFFSDGIRLKKYRGMGSLDAM
DKHLSSQNRYFSEADKIKVAQGVSGAVQDKGSIHKFVPYLIAGIQHSCQDIGAKSLTQVR
AMMYSGELKFEKRTSSAQVEGGVHSLHSYEKRLF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50116137
NameBDBM50116137
Synonyms:CHEMBL420547 | {(S)-1-[4-(3-Methoxy-4-oxazol-5-yl-phenylamino)-6-methylamino-[1,3,5]triazin-2-yl]-pyrrolidin-2-yl}-methanol
TypeSmall organic molecule
Emp. Form.C19H23N7O3
Mol. Mass.397.431
SMILESCNc1nc(Nc2ccc(-c3cnco3)c(OC)c2)nc(n1)N1CCC[C@H]1CO
Structure
n/a