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Target
Inosine-5'-monophosphate dehydrogenase 2
Ligand
BDBM50116148
Substrate
n/a
Meas. Tech.
ChEBML_89931
IC50
57.0±n/a nM
Citation
 Pitts, WJ; Guo, J; Dhar, TG; Shen, Z; Gu, HH; Watterson, SH; Bednarz, MS; Chen, BC; Barrish, JC; Bassolino, D; Cheney, D; Fleener, CA; Rouleau, KA; Hollenbaugh, DL; Iwanowicz, EJ Rapid synthesis of triazine inhibitors of inosine monophosphate dehydrogenase. Bioorg Med Chem Lett 12:2137-40 (2002) [PubMed]  Article 
Target
Name:
Inosine-5'-monophosphate dehydrogenase 2
Synonyms:
IMDH2_HUMAN | IMP dehydrogenase 2 | IMPD 2 | IMPD2 | IMPDH-II | IMPDH2 | Inosine 5'-monophosphate dehydrogenase II (IMPDH II) | Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2) | Inosine-5 -monophosphate dehydrogenase 2 | Inosine-5'-monophosphate dehydrogenase (IMPDH)
Type:
Enzyme
Mol. Mass.:
55806.87
Organism:
Homo sapiens (Human)
Description:
Recombinant IMPDH2 expressed in E. coli.
Residue:
514
Sequence:
MADYLISGGTSYVPDDGLTAQQLFNCGDGLTYNDFLILPGYIDFTADQVDLTSALTKKITLKTPLVSSPMDTVTEAGMAIAMALTGGIGFIHHNCTPEFQANEVRKVKKYEQGFITDPVVLSPKDRVRDVFEAKARHGFCGIPITDTGRMGSRLVGIISSRDIDFLKEEEHDCFLEEIMTKREDLVVAPAGITLKEANEILQRSKKGKLPIVNEDDELVAIIARTDLKKNRDYPLASKDAKKQLLCGAAIGTHEDDKYRLDLLAQAGVDVVVLDSSQGNSIFQINMIKYIKDKYPNLQVIGGNVVTAAQAKNLIDAGVDALRVGMGSGSICITQEVLACGRPQATAVYKVSEYARRFGVPVIADGGIQNVGHIAKALALGASTVMMGSLLAATTEAPGEYFFSDGIRLKKYRGMGSLDAMDKHLSSQNRYFSEADKIKVAQGVSGAVQDKGSIHKFVPYLIAGIQHSCQDIGAKSLTQVRAMMYSGELKFEKRTSSAQVEGGVHSLHSYEKRLF
  
Inhibitor
Name:
BDBM50116148
Synonyms:
6-Furan-2-yl-N-(3-methoxy-4-oxazol-5-yl-phenyl)-N'-methyl-[1,3,5]triazine-2,4-diamine | CHEMBL67163
Type:
Small organic molecule
Emp. Form.:
C18H16N6O3
Mol. Mass.:
364.358
SMILES:
CNc1nc(Nc2ccc(-c3cnco3)c(OC)c2)nc(n1)-c1ccco1
Structure:
Search PDB for entries with ligand similarity: