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Target
Neuropeptide Y receptor type 5
Ligand
BDBM50116600
Substrate
n/a
Meas. Tech.
ChEMBL_143682 (CHEMBL756249)
IC50
7±n/a nM
Citation
 Block, MH; Boyer, S; Brailsford, W; Brittain, DR; Carroll, D; Chapman, S; Clarke, DS; Donald, CS; Foote, KM; Godfrey, L; Ladner, A; Marsham, PR; Masters, DJ; Mee, CD; O'Donovan, MR; Pease, JE; Pickup, AG; Rayner, JW; Roberts, A; Schofield, P; Suleman, A; Turnbull, AV Discovery and optimization of a series of carbazole ureas as NPY5 antagonists for the treatment of obesity. J Med Chem 45:3509-23 (2002) [PubMed]  Article 
Target
Name:
Neuropeptide Y receptor type 5
Synonyms:
NPY-Y5 | NPY5R_RAT | Neuropeptide Y receptor type 5 | Npy5r | Npyr5
Type:
Enzyme Catalytic Domain
Mol. Mass.:
50435.58
Organism:
Rat 6B
Description:
NPY-Y5 NPY5R Rat 6B::Q63634
Residue:
445
Sequence:
MEFKLEEHFNKTFVTENNTAAARNAAFPAWEDYRGSVDDLQYFLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELKETFGSALLSSKYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSHKENRLEENEMINLTLQPSKKSRNQAKTPSTQKWSYSFIRKHRRRYSKKTACVLPAPAGPSQGKHLAVPENPASVRSQLSPSSKVIPGVPICFEVKPEESSDAHEMRVKRSITRIKKRSRSVFYRLTILILVFAVSWMPLHVFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLRALIHCLHMS
  
Inhibitor
Name:
BDBM50116600
Synonyms:
CHEMBL325475 | N-(9-Ethyl-9H-carbazol-3-yl)-3-pyridin-4-yl-propionamide
Type:
Small organic molecule
Emp. Form.:
C22H21N3O
Mol. Mass.:
343.4216
SMILES:
CCn1c2ccccc2c2cc(NC(=O)CCc3ccncc3)ccc12
Structure:
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