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Target
Anoctamin-1
Ligand
BDBM50239465
Substrate
n/a
Meas. Tech.
ChEMBL_2055536 (CHEMBL4710537)
IC50
30±n/a nM
Citation
 Choi, SH; Ryu, S; Sim, K; Song, C; Shin, I; Kim, SS; Lee, YS; Park, JY; Sim, T Anti-glioma effects of 2-aminothiophene-3-carboxamide derivatives, ANO1 channel blockers. Eur J Med Chem 208:0 (2020) [PubMed]  Article 
Target
Name:
Anoctamin-1
Synonyms:
ANO1_MOUSE | Ano1 | Anoctamin-1 | Tmem16a | Transmembrane protein 16A
Type:
PROTEIN
Mol. Mass.:
110928.38
Organism:
Mus musculus
Description:
ChEMBL_117479
Residue:
960
Sequence:
MRVPEKYSTLPAEDRSVHIVNICAIEDLGYLPSEGTLLNSLSVDPDAECKYGLYFRDGKRKVDYILVYHHKRASGSRTLARRGLQNDMVLGTRSVRQDQPLPGKGSPVDAGSPEVPMDYHEDDKRFRREEYEGNLLEAGLELENDEDTKIHGVGFVKIHAPWHVLCREAEFLKLKMPTKKVYHISETRGLLKTINSVLQKITDPIQPKVAEHRPQTTKRLSYPFSREKQHLFDLTDRDSFFDSKTRSTIVYEILKRTTCTKAKYSMGITSLLANGVYSAAYPLHDGDYEGDNVEFNDRKLLYEEWASYGVFYKYQPIDLVRKYFGEKVGLYFAWLGAYTQMLIPASIVGVIVFLYGCATVDENIPSMEMCDQRYNITMCPLCDKTCSYWKMSSACATARASHLFDNPATVFFSVFMALWAATFMEHWKRKQMRLNYRWDLTGFEEEEEAVKDHPRAEYEARVLEKSLRKESRNKETDKVKLTWRDRFPAYFTNLVSIIFMIAVTFAIVLGVIIYRISTAAALAMNSSPSVRSNIRVTVTATAVIINLVVIILLDEVYGCIARWLTKIEVPKTEKSFEERLTFKAFLLKFVNSYTPIFYVAFFKGRFVGRPGDYVYIFRSFRMEECAPGGCLMELCIQLSIIMLGKQLIQNNLFEIGIPKMKKFIRYLKLRRQSPSDREEYVKRKQRYEVDFNLEPFAGLTPEYMEMIIQFGFVTLFVASFPLAPLFALLNNIIEIRLDAKKFVTELRRPVAIRAKDIGIWYNILRGVGKLAVIINAFVISFTSDFIPRLVYLYMYSQNGTMHGFVNHTLSSFNVSDFQNGTAPNDPLDLGYEVQICRYKDYREPPWSEHKYDISKDFWAVLAARLAFVIVFQNLVMFMSDFVDWVIPDIPKDISQQIHKEKVLMVELFMREEQGKQQLLDTWMEKEKPRDVPCNNHSPTTHPEAGDGSPVPSYEYHGDAL
  
Inhibitor
Name:
BDBM50239465
Synonyms:
CHEMBL4080525 | US11274074, Control [Ani9]
Type:
Small organic molecule
Emp. Form.:
C17H17ClN2O3
Mol. Mass.:
332.781
SMILES:
COc1ccccc1\C=N\NC(=O)COc1ccc(Cl)cc1C
Structure:
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