Target
Caspase-6
Ligand
BDBM50119267
Substrate
n/a
Meas. Tech.
ChEMBL_46699 (CHEMBL876967)
IC50
3.5±n/a nM
Citation
 Linton, SDKaranewsky, DSTernansky, RJChen, NGuo, XJahangiri, KGKalish, VJMeduna, SPRobinson, EDUllman, BRWu, JCPham, BKodandapani, LSmidt, RDiaz, JLFritz, LCvon Krosigk, URoggo, SSchmitz, ATomaselli, KJ Acyl dipeptides as reversible caspase inhibitors. Part 2: further optimization. Bioorg Med Chem Lett 12:2973-5 (2002) [PubMed]  Article 
Target
Name:
Caspase-6
Synonyms:
Apoptotic protease Mch-2 | CASP-6 | CASP6 | CASP6_HUMAN | Caspase | MCH2
Type:
Enzyme
Mol. Mass.:
33312.62
Organism:
Homo sapiens (Human)
Description:
P55212
Residue:
293
Sequence:
MSSASGLRRGHPAGGEENMTETDAFYKREMFDPAEKYKMDHRRRGIALIFNHERFFWHLTLPERRGTCADRDNLTRRFSDLGFEVKCFNDLKAEELLLKIHEVSTVSHADADCFVCVFLSHGEGNHIYAYDAKIEIQTLTGLFKGDKCHSLVGKPKIFIIQACRGNQHDVPVIPLDVVDNQTEKLDTNITEVDAASVYTLPAGADFLMCYSVAEGYYSHRETVNGSWYIQDLCEMLGKYGSSLEFTELLTLVNRKVSQRRVDFCKDPSAIGKKQVPCFASMLTKKLHFFPKSN
  
Inhibitor
Name:
BDBM50119267
Synonyms:
4-[1-(2-Hydroxy-5-oxo-tetrahydro-furan-3-ylcarbamoyl)-3-methyl-butylcarbamoyl]-4-(naphthalen-1-yloxy)-butyric acid | CHEMBL101545
Type:
Small organic molecule
Emp. Form.:
C25H30N2O8
Mol. Mass.:
486.5143
SMILES:
CC(C)CC(NC(=O)[C@H](CCC(O)=O)Oc1cccc2ccccc12)C(=O)N[C@H]1CC(=O)OC1O
Structure:
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