Reaction Details Report a problem with these data
Target
Urokinase plasminogen activator surface receptor
Ligand
BDBM50120741
Substrate
n/a
Meas. Tech.
ChEMBL_213136 (CHEMBL817636)
IC50
>30000±n/a nM
Citation
 Schmiedeberg, N; Schmitt, M; Rölz, C; Truffault, V; Sukopp, M; Bürgle, M; Wilhelm, OG; Schmalix, W; Magdolen, V; Kessler, H Synthesis, solution structure, and biological evaluation of urokinase type plasminogen activator (uPA)-derived receptor binding domain mimetics. J Med Chem 45:4984-94 (2002) [PubMed]  Article 
Target
Name:
Urokinase plasminogen activator surface receptor
Synonyms:
CD_antigen=CD87 | MO3 | Monocyte activation antigen Mo3 | PLAUR | U-PAR | UPAR | UPAR_HUMAN | Urokinase plasminogen activator surface receptor | Urokinase receptor (uPAR) | Urokinase-type plasminogen activator/surface receptor
Type:
Receptor
Mol. Mass.:
36979.14
Organism:
Homo sapiens (Human)
Description:
Q03405
Residue:
335
Sequence:
MGHPPLLPLLLLLHTCVPASWGLRCMQCKTNGDCRVEECALGQDLCRTTIVRLWEEGEELELVEKSCTHSEKTNRTLSYRTGLKITSLTEVVCGLDLCNQGNSGRAVTYSRSRYLECISCGSSDMSCERGRHQSLQCRSPEEQCLDVVTHWIQEGEEGRPKDDRHLRGCGYLPGCPGSNGFHNNDTFHFLKCCNTTKCNEGPILELENLPQNGRQCYSCKGNSTHGCSSEETFLIDCRGPMNQCLVATGTHEPKNQSYMVRGCATASMCQHAHLGDAFSMNHIDVSCCTKSGCNHPDLDVQYRSGAAPQPGPAHLSLTITLLMTARLWGGTLLWT
  
Inhibitor
Name:
BDBM50120741
Synonyms:
CHEMBL437837 | cyclic uPA-derived peptide
Type:
Small organic molecule
Emp. Form.:
C45H68N16O17S2
Mol. Mass.:
1169.248
SMILES:
CC(C)C[C@H]1NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](CC(N)=O)NC(=O)[C@H](N)CSSC[C@@H](NC(=O)[C@H]2CCCN2C(=O)[C@H](CC(N)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O)C(=O)N[C@@H](CC(N)=O)C(O)=O
Structure:
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