Target
Orexin receptor type 2
Ligand
BDBM50121766
Substrate
n/a
Meas. Tech.
ChEMBL_323054 (CHEMBL857325)
EC50
0.19±n/a nM
Citation
 Asahi, SEgashira, SMatsuda, MIwaasa, HKanatani, AOhkubo, MIhara, MMorishima, H Development of an orexin-2 receptor selective agonist, [Ala(11), D-Leu(15)]orexin-B. Bioorg Med Chem Lett 13:111-3 (2002) [PubMed]  Article 
Target
Name:
Orexin receptor type 2
Synonyms:
HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R
Type:
Protein
Mol. Mass.:
50710.53
Organism:
Homo sapiens (Human)
Description:
O43614
Residue:
444
Sequence:
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
  
Inhibitor
Name:
BDBM50121766
Synonyms:
CHEMBL410816 | [D-Arg1]orexin-B
Type:
Small organic molecule
Emp. Form.:
C123H212N44O35S
Mol. Mass.:
2899.338
SMILES:
CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](N)CCSC)[C@@H](C)O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@H](CCCN=C(N)N)C(N)=O |wU:74.75,124.124,68.68,192.194,56.56,41.41,104.104,2.2,186.188,8.12,88.88,20.20,79.79,wD:156.156,115.115,147.147,46.45,36.36,4.4,96.96,16.16,26.27,132.132,171.173,178.181,(18.14,-16.31,;18.14,-17.85,;16.81,-18.62,;15.47,-17.85,;16.81,-20.16,;18.14,-20.93,;19.48,-20.16,;19.48,-18.62,;20.82,-20.93,;20.82,-22.47,;19.48,-23.24,;19.48,-24.78,;18.15,-22.47,;22.15,-20.16,;23.48,-20.93,;23.48,-22.47,;24.82,-20.16,;26.15,-20.93,;27.48,-20.16,;27.48,-18.62,;28.82,-20.93,;30.16,-20.16,;28.82,-22.47,;27.48,-23.24,;27.49,-24.78,;26.17,-25.55,;24.82,-18.62,;26.15,-17.85,;23.48,-17.85,;15.47,-20.93,;15.47,-22.47,;14.15,-20.16,;12.82,-20.93,;11.48,-20.16,;11.48,-18.62,;10.15,-20.94,;8.82,-20.17,;8.82,-18.63,;7.48,-20.94,;7.48,-22.48,;6.14,-20.16,;4.81,-20.93,;4.81,-22.47,;3.47,-20.16,;3.47,-18.62,;2.14,-20.94,;.81,-20.17,;.81,-18.63,;-.53,-17.86,;-1.75,-18.8,;-3.02,-17.92,;-2.58,-16.45,;-1.05,-16.41,;-.53,-20.94,;-.53,-22.48,;-1.86,-20.16,;-3.19,-20.93,;-3.19,-22.47,;-4.53,-23.24,;-5.86,-22.47,;-4.53,-24.78,;-4.53,-20.16,;-4.53,-18.62,;-5.87,-20.94,;-7.19,-20.18,;-7.19,-18.64,;-5.86,-17.87,;-8.52,-17.86,;-8.49,-16.35,;-9.78,-15.54,;-9.74,-14.01,;-7.13,-15.61,;-5.82,-16.41,;-7.09,-14.07,;-5.76,-13.3,;-5.76,-11.76,;-4.42,-14.07,;-4.42,-15.61,;-3.09,-13.3,;-3.1,-11.76,;-4.44,-11,;-4.45,-9.45,;-5.79,-8.7,;-7.1,-9.48,;-5.79,-7.15,;-1.76,-10.98,;-1.78,-9.44,;-.43,-11.75,;.9,-10.98,;.9,-9.44,;2.24,-8.67,;2.24,-7.13,;3.58,-9.44,;2.24,-11.75,;2.24,-13.29,;3.58,-10.98,;4.91,-11.75,;4.91,-13.29,;6.25,-14.06,;6.25,-15.6,;7.58,-13.29,;6.25,-10.98,;6.25,-9.44,;7.58,-11.75,;8.91,-10.98,;8.91,-9.44,;10.25,-8.67,;10.25,-7.13,;11.59,-6.38,;12.93,-7.15,;14.26,-6.38,;12.93,-8.68,;10.25,-11.75,;10.25,-13.29,;11.58,-10.97,;12.91,-11.74,;12.91,-13.28,;14.25,-14.05,;14.25,-15.59,;15.58,-16.36,;12.91,-16.36,;14.25,-10.97,;14.25,-9.43,;15.58,-11.74,;16.91,-10.97,;16.91,-9.43,;18.25,-8.66,;18.25,-7.12,;19.58,-9.43,;18.25,-11.74,;18.25,-13.28,;19.58,-10.97,;20.91,-11.74,;20.91,-13.28,;22.25,-14.05,;22.25,-15.59,;23.59,-16.36,;24.92,-15.59,;26.26,-16.36,;24.93,-14.05,;22.25,-10.97,;22.25,-9.43,;23.59,-11.74,;24.92,-10.99,;24.93,-9.44,;23.59,-8.67,;26.25,-8.67,;26.27,-7.14,;27.6,-6.38,;27.61,-4.83,;28.95,-4.07,;28.97,-2.53,;30.28,-4.86,;24.93,-6.35,;23.6,-7.11,;24.95,-4.81,;23.62,-4.04,;23.63,-2.52,;24.97,-1.75,;24.97,-.21,;26.3,-2.52,;22.28,-4.81,;22.28,-6.35,;20.95,-4.04,;19.61,-4.81,;18.29,-4.04,;16.96,-4.82,;18.28,-2.5,;19.53,-1.59,;19.05,-.13,;17.51,-.13,;17.04,-1.59,;15.71,-2.37,;15.72,-3.91,;14.36,-1.62,;13.89,-.16,;12.35,-.16,;11.87,-1.62,;13.12,-2.54,;13.12,-4.08,;14.45,-4.85,;11.78,-4.86,;10.45,-4.09,;9.11,-4.86,;9.11,-6.4,;7.77,-4.09,;6.44,-4.86,;6.44,-6.4,;5.1,-7.17,;5.1,-4.09,;5.1,-2.55,;3.78,-4.86,;2.45,-4.09,;2.45,-2.55,;1.11,-1.78,;1.11,-.24,;-.21,.53,;-1.55,-.23,;-2.88,.54,;-1.55,-1.77,;1.11,-4.86,;-.23,-4.08,;1.11,-6.4,)|
Structure:
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