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Target
N-formyl peptide receptor 2
Ligand
BDBM50559838
Substrate
n/a
Meas. Tech.
ChEMBL_2070440 (CHEMBL4725974)
EC50
0.078000±n/a nM
Citation
 Asahina, Y; Wurtz, NR; Arakawa, K; Carson, N; Fujii, K; Fukuchi, K; Garcia, R; Hsu, MY; Ishiyama, J; Ito, B; Kick, E; Lupisella, J; Matsushima, S; Ohata, K; Ostrowski, J; Saito, Y; Tsuda, K; Villarreal, F; Yamada, H; Yamaoka, T; Wexler, R; Gordon, D; Kohno, Y Discovery of BMS-986235/LAR-1219: A Potent Formyl Peptide Receptor 2 (FPR2) Selective Agonist for the Prevention of Heart Failure. J Med Chem 63:9003-9019 (2020) [PubMed]  Article 
Target
Name:
N-formyl peptide receptor 2
Synonyms:
ALXR, FPRL1, FPR2 | FMLP-related receptor I FMLP-R-I | FPR2 | FPR2_HUMAN | FPRH1 | FPRL1 | Formyl Peptide Receptor-Like 1 | HM63 | LXA4 receptor | LXA4R | Lipoxin A4 receptor | Lipoxin A4 receptor (LXA4) | RFP | hFPRL
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
38968.35
Organism:
Homo sapiens (Human)
Description:
P25090
Residue:
351
Sequence:
METNFSTPLNEYEEVSYESAGYTVLRILPLVVLGVTFVLGVLGNGLVIWVAGFRMTRTVTTICYLNLALADFSFTATLPFLIVSMAMGEKWPFGWFLCKLIHIVVDINLFGSVFLIGFIALDRCICVLHPVWAQNHRTVSLAMKVIVGPWILALVLTLPVFLFLTTVTIPNGDTYCTFNFASWGGTPEERLKVAITMLTARGIIRFVIGFSLPMSIVAICYGLIAAKIHKKGMIKSSRPLRVLTAVVASFFICWFPFQLVALLGTVWLKEMLFYGKYKIIDILVNPTSSLAFFNSCLNPMLYVFVGQDFRERLIHSLPTSLERALSEDSAPTNDTAANSASPPAETELQAM
  
Inhibitor
Name:
BDBM50559838
Synonyms:
CHEMBL4790836
Type:
Small organic molecule
Emp. Form.:
C19H19F2N3O4
Mol. Mass.:
391.3687
SMILES:
COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(C)c(O)c2)c(F)c1 |r|
Structure:
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