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Target
Formyl peptide receptor 2
Ligand
BDBM50559840
Substrate
n/a
Meas. Tech.
ChEMBL_2070443 (CHEMBL4725977)
EC50
1.4±n/a nM
Citation
 Asahina, Y; Wurtz, NR; Arakawa, K; Carson, N; Fujii, K; Fukuchi, K; Garcia, R; Hsu, MY; Ishiyama, J; Ito, B; Kick, E; Lupisella, J; Matsushima, S; Ohata, K; Ostrowski, J; Saito, Y; Tsuda, K; Villarreal, F; Yamada, H; Yamaoka, T; Wexler, R; Gordon, D; Kohno, Y Discovery of BMS-986235/LAR-1219: A Potent Formyl Peptide Receptor 2 (FPR2) Selective Agonist for the Prevention of Heart Failure. J Med Chem 63:9003-9019 (2020) [PubMed]  Article 
Target
Name:
Formyl peptide receptor 2
Synonyms:
FPR2_MOUSE | Formyl peptide receptor 2 | Formylpeptide receptor-related sequence 2 | Fpr-rs2 | Fpr2 | Lipoxin A4 receptor-like protein | N-formylpeptide receptor-like 2
Type:
PROTEIN
Mol. Mass.:
39427.03
Organism:
Mus musculus
Description:
ChEMBL_120178
Residue:
351
Sequence:
MESNYSIHLNGSEVVVYDSTISRVLWILSMVVVSITFFLGVLGNGLVIWVAGFRMPHTVTTIWYLNLALADFSFTATLPFLLVEMAMKEKWPFGWFLCKLVHIVVDVNLFGSVFLIALIALDRCICVLHPVWAQNHRTVSLARKVVVGPWIFALILTLPIFIFLTTVRIPGGDVYCTFNFGSWAQTDEEKLNTAITFVTTRGIIRFLIGFSMPMSIVAVCYGLIAVKINRRNLVNSSRPLRVLTAVVASFFICWFPFQLVALLGTVWFKETLLSGSYKILDMFVNPTSSLAYFNSCLNPMLYVFMGQDFRERFIHSLPYSLERALSEDSGQTSDSSTSSTSPPADIELKAP
  
Inhibitor
Name:
BDBM50559840
Synonyms:
CHEMBL4760897
Type:
Small organic molecule
Emp. Form.:
C16H14ClF2N3O3S
Mol. Mass.:
401.815
SMILES:
COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(Cl)s2)c(F)c1 |r|
Structure:
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