Reaction Details Report a problem with these data
Target
N-terminal Xaa-Pro-Lys N-methyltransferase 2
Ligand
BDBM50560066
Substrate
n/a
Meas. Tech.
ChEMBL_2071337 (CHEMBL4726871)
Kd
1000±n/a nM
Citation
 Mackie, BD; Chen, D; Dong, G; Dong, C; Parker, H; Schaner Tooley, CE; Noinaj, N; Min, J; Huang, R Selective Peptidomimetic Inhibitors of NTMT1/2: Rational Design, Synthesis, Characterization, and Crystallographic Studies. J Med Chem 63:9512-9522 (2020) [PubMed]  Article 
Target
Name:
N-terminal Xaa-Pro-Lys N-methyltransferase 2
Synonyms:
2.1.1.299 | Alpha N-terminal protein methyltransferase 1B | C1orf184 | METTL11B | Methyltransferase-like protein 11B | N-terminal Xaa-Pro-Lys N-methyltransferase 2 | NRMT2 | NTM1B | NTM1B_HUMAN | NTMT2 | Synonyms=C1orf184 | X-Pro-Lys N-terminal protein methyltransferase 1B
Type:
PROTEIN
Mol. Mass.:
32402.46
Organism:
Homo sapiens
Description:
ChEMBL_119927
Residue:
283
Sequence:
MAHRGAHFAFRSRWQKTDDELCRHSMSFILHKAIRNDFFQSYLYLLEKIPLVKLYALTSQVINGEMQFYARAKLFYQEVPATEEGMMGNFIELSSPDIQASQKFLRKFVGGPGRAGTDCALDCGSGIGRVSKHVLLPVFNSVELVDMMESFLLEAQNYLQVKGDKVESYHCYSLQEFTPPFRRYDVIWIQWVSGHLTDKDLLAFLSRCRDGLKENGIIILKDNVAREGCILDLSDSSVTRDMDILRSLIRKSGLVVLGQEKQDGFPEQCIPVWMFALHSDRHS
  
Inhibitor
Name:
BDBM50560066
Synonyms:
CHEMBL4787034
Type:
Small organic molecule
Emp. Form.:
C55H100N28O10
Mol. Mass.:
1313.5641
SMILES:
NCCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O |r|
Structure:
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