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Target
Thyroid hormone receptor beta
Ligand
BDBM50123059
Substrate
n/a
Meas. Tech.
ChEBML_210497
Ki
0.370±n/a nM
Citation
 Dow, RL; Schneider, SR; Paight, ES; Hank, RF; Chiang, P; Cornelius, P; Lee, E; Newsome, WP; Swick, AG; Spitzer, J; Hargrove, DM; Patterson, TA; Pandit, J; Chrunyk, BA; LeMotte, PK; Danley, DE; Rosner, MH; Ammirati, MJ; Simons, SP; Schulte, GK; Tate, BF; DaSilva-Jardine, P Discovery of a novel series of 6-azauracil-based thyroid hormone receptor ligands: potent, TR beta subtype-selective thyromimetics. Bioorg Med Chem Lett 13:379-82 (2003) [PubMed]  Article 
Target
Name:
Thyroid hormone receptor beta
Synonyms:
ERBA2 | NR1A2 | Nuclear receptor subfamily 1 group A member 2 | THB_HUMAN | THR1 | THRB | c-erbA-2 | c-erbA-beta
Type:
Receptor
Mol. Mass.:
52793.62
Organism:
Homo sapiens (Human)
Description:
Recombinant hThR was obtained from nuclear extracts from SF9 cells infected with baculovirus vectors encoding for ThRbeta 1.
Residue:
461
Sequence:
MTPNSMTENGLTAWDKPKHCPDREHDWKLVGMSEACLHRKSHSERRSTLKNEQSSPHLIQTTWTSSIFHLDHDDVNDQSVSSAQTFQTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED
  
Inhibitor
Name:
BDBM50123059
Synonyms:
2-{4-[3-(2-Aza-bicyclo[2.2.1]heptane-2-carbonyl)-4-hydroxy-phenoxy]-3,5-dichloro-phenyl}-2H-[1,2,4]triazine-3,5-dione | CHEMBL338602
Type:
Small organic molecule
Emp. Form.:
C22H18Cl2N4O5
Mol. Mass.:
489.308
SMILES:
Oc1ccc(Oc2c(Cl)cc(cc2Cl)-n2ncc(=O)[nH]c2=O)cc1C(=O)N1CC2CCC1C2
Structure:
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