Target
Inosine-5'-monophosphate dehydrogenase 2
Ligand
BDBM50123354
Substrate
n/a
Meas. Tech.
ChEBML_89930
IC50
25±n/a nM
Citation
 Dhar, TGWatterson, SHChen, PShen, ZGu, HHNorris, DCarlsen, MHaslow, KDPitts, WJGuo, JChorba, JFleener, CARouleau, KATownsend, RHollenbaugh, DIwanowicz, EJ Quinolone-based IMPDH inhibitors: introduction of basic residues on ring D and SAR of the corresponding mono, di and benzofused analogues. Bioorg Med Chem Lett 13:547-51 (2003) [PubMed]  Article 
Target
Name:
Inosine-5'-monophosphate dehydrogenase 2
Synonyms:
IMDH2_HUMAN | IMP dehydrogenase 2 | IMPD 2 | IMPD2 | IMPDH-II | IMPDH2 | Inosine 5'-monophosphate dehydrogenase II (IMPDH II) | Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2) | Inosine-5 -monophosphate dehydrogenase 2 | Inosine-5'-monophosphate dehydrogenase (IMPDH)
Type:
Enzyme
Mol. Mass.:
55806.87
Organism:
Homo sapiens (Human)
Description:
Recombinant IMPDH2 expressed in E. coli.
Residue:
514
Sequence:
MADYLISGGTSYVPDDGLTAQQLFNCGDGLTYNDFLILPGYIDFTADQVDLTSALTKKITLKTPLVSSPMDTVTEAGMAIAMALTGGIGFIHHNCTPEFQANEVRKVKKYEQGFITDPVVLSPKDRVRDVFEAKARHGFCGIPITDTGRMGSRLVGIISSRDIDFLKEEEHDCFLEEIMTKREDLVVAPAGITLKEANEILQRSKKGKLPIVNEDDELVAIIARTDLKKNRDYPLASKDAKKQLLCGAAIGTHEDDKYRLDLLAQAGVDVVVLDSSQGNSIFQINMIKYIKDKYPNLQVIGGNVVTAAQAKNLIDAGVDALRVGMGSGSICITQEVLACGRPQATAVYKVSEYARRFGVPVIADGGIQNVGHIAKALALGASTVMMGSLLAATTEAPGEYFFSDGIRLKKYRGMGSLDAMDKHLSSQNRYFSEADKIKVAQGVSGAVQDKGSIHKFVPYLIAGIQHSCQDIGAKSLTQVRAMMYSGELKFEKRTSSAQVEGGVHSLHSYEKRLF
  
Inhibitor
Name:
BDBM50123354
Synonyms:
7-Methoxy-6-oxazol-5-yl-2-(3-pyrrolidin-1-yl-phenyl)-1H-quinolin-4-one | CHEMBL153702
Type:
Small organic molecule
Emp. Form.:
C23H21N3O3
Mol. Mass.:
387.4311
SMILES:
COc1cc2nc(cc(O)c2cc1-c1cnco1)-c1cccc(c1)N1CCCC1
Structure:
Search PDB for entries with ligand similarity: