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Target
Inosine-5'-monophosphate dehydrogenase 2
Ligand
BDBM50123374
Substrate
n/a
Meas. Tech.
ChEBML_89930
IC50
68.0±n/a nM
Citation
 Dhar, TG; Watterson, SH; Chen, P; Shen, Z; Gu, HH; Norris, D; Carlsen, M; Haslow, KD; Pitts, WJ; Guo, J; Chorba, J; Fleener, CA; Rouleau, KA; Townsend, R; Hollenbaugh, D; Iwanowicz, EJ Quinolone-based IMPDH inhibitors: introduction of basic residues on ring D and SAR of the corresponding mono, di and benzofused analogues. Bioorg Med Chem Lett 13:547-51 (2003) [PubMed]  Article 
Target
Name:
Inosine-5'-monophosphate dehydrogenase 2
Synonyms:
IMDH2_HUMAN | IMP dehydrogenase 2 | IMPD 2 | IMPD2 | IMPDH-II | IMPDH2 | Inosine 5'-monophosphate dehydrogenase II (IMPDH II) | Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2) | Inosine-5 -monophosphate dehydrogenase 2 | Inosine-5'-monophosphate dehydrogenase (IMPDH)
Type:
Enzyme
Mol. Mass.:
55806.87
Organism:
Homo sapiens (Human)
Description:
Recombinant IMPDH2 expressed in E. coli.
Residue:
514
Sequence:
MADYLISGGTSYVPDDGLTAQQLFNCGDGLTYNDFLILPGYIDFTADQVDLTSALTKKITLKTPLVSSPMDTVTEAGMAIAMALTGGIGFIHHNCTPEFQANEVRKVKKYEQGFITDPVVLSPKDRVRDVFEAKARHGFCGIPITDTGRMGSRLVGIISSRDIDFLKEEEHDCFLEEIMTKREDLVVAPAGITLKEANEILQRSKKGKLPIVNEDDELVAIIARTDLKKNRDYPLASKDAKKQLLCGAAIGTHEDDKYRLDLLAQAGVDVVVLDSSQGNSIFQINMIKYIKDKYPNLQVIGGNVVTAAQAKNLIDAGVDALRVGMGSGSICITQEVLACGRPQATAVYKVSEYARRFGVPVIADGGIQNVGHIAKALALGASTVMMGSLLAATTEAPGEYFFSDGIRLKKYRGMGSLDAMDKHLSSQNRYFSEADKIKVAQGVSGAVQDKGSIHKFVPYLIAGIQHSCQDIGAKSLTQVRAMMYSGELKFEKRTSSAQVEGGVHSLHSYEKRLF
  
Inhibitor
Name:
BDBM50123374
Synonyms:
2-Imidazol-1-yl-N-[6-(7-methoxy-6-oxazol-5-yl-4-oxo-1,4-dihydro-quinolin-2-yl)-indan-1-yl]-N-methyl-acetamide | CHEMBL153595
Type:
Small organic molecule
Emp. Form.:
C28H25N5O4
Mol. Mass.:
495.5292
SMILES:
COc1cc2nc(cc(O)c2cc1-c1cnco1)-c1ccc2CCC(N(C)C(=O)Cn3ccnc3)c2c1
Structure:
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