Target
Growth factor receptor-bound protein 2
Ligand
BDBM50124296
Substrate
n/a
Meas. Tech.
ChEBML_72365
IC50
1.7±n/a nM
Citation
 Li, PPeach, MLZhang, MLiu, HYang, DNicklaus, MRoller, PP Structure-based design of thioether-bridged cyclic phosphopeptides binding to Grb2-SH2 domain. Bioorg Med Chem Lett 13:895-9 (2003) [PubMed]  Article 
Target
Name:
Growth factor receptor-bound protein 2
Synonyms:
ASH | GRB2 | GRB2 adapter protein | GRB2_HUMAN | Grb2-SH2 | Growth factor receptor-bound protein 2
Type:
Protein
Mol. Mass.:
25205.04
Organism:
Homo sapiens (Human)
Description:
P62993
Residue:
217
Sequence:
MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
  
Inhibitor
Name:
BDBM50124296
Synonyms:
12-benzyl-36-carbamoylmethyl-9-(4-phosphonooxybenzyl)-24-(4-hydroxybenzyl)-33-isopropyl-15-methyl-27-neopentyl-8,11,14,17,23,26,29,32,35,38-decaoxo-19-thia-7,10,13,16,22,25,28,31,34,37-decaazaspiro[5.32]octatriacontane-21-carboxamide | CHEMBL439878
Type:
Small organic molecule
Emp. Form.:
C60H83N12O17PS
Mol. Mass.:
1307.41
SMILES:
CC(C)[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)C2(CCCCC2)NC(=O)[C@H](Cc2ccc(OP(O)(O)=O)cc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](C)NC(=O)CSC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CC(C)(C)C)NC(=O)CNC1=O)C(N)=O
Structure:
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