Reaction Details Report a problem with these data
Target
Growth factor receptor-bound protein 2
Ligand
BDBM50124301
Substrate
n/a
Meas. Tech.
ChEBML_72365
IC50
3.8±n/a nM
Citation
 Li, P; Peach, ML; Zhang, M; Liu, H; Yang, D; Nicklaus, M; Roller, PP Structure-based design of thioether-bridged cyclic phosphopeptides binding to Grb2-SH2 domain. Bioorg Med Chem Lett 13:895-9 (2003) [PubMed]  Article 
Target
Name:
Growth factor receptor-bound protein 2
Synonyms:
ASH | GRB2 | GRB2 adapter protein | GRB2_HUMAN | Grb2-SH2 | Growth factor receptor-bound protein 2
Type:
Protein
Mol. Mass.:
25205.04
Organism:
Homo sapiens (Human)
Description:
P62993
Residue:
217
Sequence:
MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
  
Inhibitor
Name:
BDBM50124301
Synonyms:
2-[9-(4-phosphonooxybenzyl)-21-carbamoyl-24-(4-hydroxybenzyl)-12-isobutyl-33-isopropyl-15-methyl-27-(2-methylsulfanylethyl)-8,11,14,17,23,26,29,32,35,38-decaoxo-19-thia-7,10,13,16,22,25,28,31,34,37-decaazaspiro[5.32]octatriacont-36-yl]acetamide | CHEMBL2371612
Type:
Small organic molecule
Emp. Form.:
C55H81N12O17PS2
Mol. Mass.:
1277.406
SMILES:
CSCC[C@@H]1NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)C2(CCCCC2)NC(=O)[C@H](Cc2ccc(OP(O)(O)=O)cc2)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)CSC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O)C(N)=O)C(C)C
Structure:
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