Reaction Details Report a problem with these data
Target
Kinesin-like protein KIF18A
Ligand
BDBM50561740
Substrate
n/a
Meas. Tech.
ChEMBL_2075814 (CHEMBL4731348)
IC50
12±n/a nM
Citation
 Sabnis, RW Novel KIF18A Inhibitors for Treating Cancer. ACS Med Chem Lett 11:2079-2080 (2020) [PubMed]  Article 
Target
Name:
Kinesin-like protein KIF18A
Synonyms:
KI18A_HUMAN | KIF18A | Kinesin-like protein KIF18A | MS-KIF18A | Marrow stromal KIF18A
Type:
PROTEIN
Mol. Mass.:
102320.22
Organism:
Homo sapiens
Description:
ChEMBL_119153
Residue:
898
Sequence:
MSVTEEDLCHHMKVVVRVRPENTKEKAAGFHKVVHVVDKHILVFDPKQEEVSFFHGKKTTNQNVIKKQNKDLKFVFDAVFDETSTQSEVFEHTTKPILRSFLNGYNCTVLAYGATGAGKTHTMLGSADEPGVMYLTMLHLYKCMDEIKEEKICSTAVSYLEVYNEQIRDLLVNSGPLAVREDTQKGVVVHGLTLHQPKSSEEILHLLDNGNKNRTQHPTDMNATSSRSHAVFQIYLRQQDKTASINQNVRIAKMSLIDLAGSERASTSGAKGTRFVEGTNINRSLLALGNVINALADSKRKNQHIPYRNSKLTRLLKDSLGGNCQTIMIAAVSPSSVFYDDTYNTLKYANRAKDIKSSLKSNVLNVNNHITQYVKICNEQKAEILLLKEKLKAYEEQKAFTNENDQAKLMISNPQEKEIERFQEILNCLFQNREEIRQEYLKLEMLLKENELKSFYQQQCHKQIEMMCSEDKVEKATGKRDHRLAMLKTRRSYLEKRREEELKQFDENTNWLHRVEKEMGLLSQNGHIPKELKKDLHCHHLHLQNKDLKAQIRHMMDLACLQEQQHRQTEAVLNALLPTLRKQYCTLKEAGLSNAAFESDFKEIEHLVERKKVVVWADQTAEQPKQNDLPGISVLMTFPQLGPVQPIPCCSSSGGTNLVKIPTEKRTRRKLMPSPLKGQHTLKSPPSQSVQLNDSLSKELQPIVYTPEDCRKAFQNPSTVTLMKPSSFTTSFQAISSNINSDNCLKMLCEVAIPHNRRKECGQEDLDSTFTICEDIKSSKCKLPEQESLPNDNKDILQRLDPSSFSTKHSMPVPSMVPSYMAMTTAAKRKRKLTSSTSNSSLTADVNSGFAKRVRQDNSSEKHLQENKPTMEHKRNICKINPSMVRKFGRNISKGNLR
  
Inhibitor
Name:
BDBM50561740
Synonyms:
CHEMBL4755023
Type:
Small organic molecule
Emp. Form.:
C24H29F3N4O5S
Mol. Mass.:
542.571
SMILES:
OCCNS(=O)(=O)c1ccc(C(=O)Nc2cccc(OCCC(F)(F)F)n2)c(c1)N1CCC2(CC2)CC1
Structure:
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