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Target
Kinesin-like protein KIF18A
Ligand
BDBM50561923
Substrate
n/a
Meas. Tech.
ChEMBL_2076314 (CHEMBL4731848)
IC50
17±n/a nM
Citation
 Sabnis, RW Novel KIF18A Inhibitors for Treating Cancer. ACS Med Chem Lett 11:2368-2369 (2020) [PubMed]  Article 
Target
Name:
Kinesin-like protein KIF18A
Synonyms:
KI18A_HUMAN | KIF18A | Kinesin-like protein KIF18A | MS-KIF18A | Marrow stromal KIF18A
Type:
PROTEIN
Mol. Mass.:
102320.22
Organism:
Homo sapiens
Description:
ChEMBL_119153
Residue:
898
Sequence:
MSVTEEDLCHHMKVVVRVRPENTKEKAAGFHKVVHVVDKHILVFDPKQEEVSFFHGKKTTNQNVIKKQNKDLKFVFDAVFDETSTQSEVFEHTTKPILRSFLNGYNCTVLAYGATGAGKTHTMLGSADEPGVMYLTMLHLYKCMDEIKEEKICSTAVSYLEVYNEQIRDLLVNSGPLAVREDTQKGVVVHGLTLHQPKSSEEILHLLDNGNKNRTQHPTDMNATSSRSHAVFQIYLRQQDKTASINQNVRIAKMSLIDLAGSERASTSGAKGTRFVEGTNINRSLLALGNVINALADSKRKNQHIPYRNSKLTRLLKDSLGGNCQTIMIAAVSPSSVFYDDTYNTLKYANRAKDIKSSLKSNVLNVNNHITQYVKICNEQKAEILLLKEKLKAYEEQKAFTNENDQAKLMISNPQEKEIERFQEILNCLFQNREEIRQEYLKLEMLLKENELKSFYQQQCHKQIEMMCSEDKVEKATGKRDHRLAMLKTRRSYLEKRREEELKQFDENTNWLHRVEKEMGLLSQNGHIPKELKKDLHCHHLHLQNKDLKAQIRHMMDLACLQEQQHRQTEAVLNALLPTLRKQYCTLKEAGLSNAAFESDFKEIEHLVERKKVVVWADQTAEQPKQNDLPGISVLMTFPQLGPVQPIPCCSSSGGTNLVKIPTEKRTRRKLMPSPLKGQHTLKSPPSQSVQLNDSLSKELQPIVYTPEDCRKAFQNPSTVTLMKPSSFTTSFQAISSNINSDNCLKMLCEVAIPHNRRKECGQEDLDSTFTICEDIKSSKCKLPEQESLPNDNKDILQRLDPSSFSTKHSMPVPSMVPSYMAMTTAAKRKRKLTSSTSNSSLTADVNSGFAKRVRQDNSSEKHLQENKPTMEHKRNICKINPSMVRKFGRNISKGNLR
  
Inhibitor
Name:
BDBM50561923
Synonyms:
CHEMBL4751673 | US11236069, Example 6-24-1
Type:
Small organic molecule
Emp. Form.:
C26H36N6O5S
Mol. Mass.:
544.666
SMILES:
C[C@@H](CO)S(=O)(=O)Nc1ccc(C(=O)Nc2ccnc(n2)N2CCO[C@H](C)C2)c(c1)N1CCC2(CC2)CC1 |r|
Structure:
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