Reaction Details Report a problem with these data
Target
Coagulation factor X
Ligand
BDBM50124977
Substrate
n/a
Meas. Tech.
ChEBML_49131
IC50
17±n/a nM
Citation
Huang, W; Naughton, MA; Yang, H; Su, T; Dam, S; Wong, PW; Arfsten, A; Edwards, S; Sinha, U; Hollenbach, S; Scarborough, RM; Zhu, BY Design, synthesis, and structure-activity relationships of unsubstituted piperazinone-based transition state factor Xa inhibitors. Bioorg Med Chem Lett 13:723-8 (2003) [PubMed] Article
More Info.:
Target
Name:
Coagulation factor X
Synonyms:
Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:
Enzyme
Mol. Mass.:
54726.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK
Inhibitor
Name:
BDBM50124977
Synonyms:
2-{4-[2-(4-Chloro-phenyl)-acetyl]-2-oxo-piperazin-1-yl}-N-[(R)-4-guanidino-1-(thiazole-2-carbonyl)-butyl]-acetamide | CHEMBL162909
Type:
Small organic molecule
Emp. Form.:
C23H28ClN7O4S
Mol. Mass.:
534.031
SMILES:
NC(=N)NCCC[C@@H](NC(=O)CN1CCN(CC1=O)C(=O)Cc1ccc(Cl)cc1)C(=O)c1nccs1