Reaction Details Report a problem with these data
Target
Coagulation factor X
Ligand
BDBM50124996
Substrate
n/a
Meas. Tech.
ChEBML_49131
IC50
13±n/a nM
Citation
 Huang, W; Naughton, MA; Yang, H; Su, T; Dam, S; Wong, PW; Arfsten, A; Edwards, S; Sinha, U; Hollenbach, S; Scarborough, RM; Zhu, BY Design, synthesis, and structure-activity relationships of unsubstituted piperazinone-based transition state factor Xa inhibitors. Bioorg Med Chem Lett 13:723-8 (2003) [PubMed]  Article 
Target
Name:
Coagulation factor X
Synonyms:
Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:
Enzyme
Mol. Mass.:
54726.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK
  
Inhibitor
Name:
BDBM50124996
Synonyms:
CHEMBL265997 | N-[4-Guanidino-1-(thiazole-2-carbonyl)-butyl]-2-[2-oxo-4-((E)-2-phenyl-ethenesulfonyl)-piperazin-1-yl]-acetamide
Type:
Small organic molecule
Emp. Form.:
C23H29N7O5S2
Mol. Mass.:
547.65
SMILES:
NC(=N)NCCCC(NC(=O)CN1CCN(CC1=O)S(=O)(=O)C=Cc1ccccc1)C(=O)c1nccs1 |w:23.24|
Structure:
Search PDB for entries with ligand similarity: