Reaction Details Report a problem with these data
Target
Forkhead box protein M1
Ligand
BDBM50085045
Substrate
n/a
Meas. Tech.
ChEMBL_2077765 (CHEMBL4733556)
Ki
52±n/a nM
Citation
 Tabatabaei Dakhili, SA; Pérez, DJ; Gopal, K; Haque, M; Ussher, JR; Kashfi, K; Velázquez-Martínez, CA SP1-independent inhibition of FOXM1 by modified thiazolidinediones. Eur J Med Chem 209:0 (2021) [PubMed]  Article 
Target
Name:
Forkhead box protein M1
Synonyms:
FKHL16 | FOXM1 | FOXM1_HUMAN | Forkhead box protein M1 | Forkhead-related protein FKHL16 | HFH-11 | HFH11 | HNF-3/fork-head homolog 11 | Hepatocyte nuclear factor 3 forkhead homolog 11 | M-phase phosphoprotein 2 | MPM-2 reactive phosphoprotein 2 | MPP2 | Transcription factor Trident | WIN | Winged-helix factor from INS-1 cells
Type:
PROTEIN
Mol. Mass.:
84290.86
Organism:
Homo sapiens
Description:
ChEMBL_120188
Residue:
763
Sequence:
MKTSPRRPLILKRRRLPLPVQNAPSETSEEEPKRSPAQQESNQAEASKEVAESNSCKFPAGIKIINHPTMPNTQVVAIPNNANIHSIITALTAKGKESGSSGPNKFILISCGGAPTQPPGLRPQTQTSYDAKRTEVTLETLGPKPAARDVNLPRPPGALCEQKRETCADGEAAGCTINNSLSNIQWLRKMSSDGLGSRSIKQEMEEKENCHLEQRQVKVEEPSRPSASWQNSVSERPPYSYMAMIQFAINSTERKRMTLKDIYTWIEDHFPYFKHIAKPGWKNSIRHNLSLHDMFVRETSANGKVSFWTIHPSANRYLTLDQVFKPLDPGSPQLPEHLESQQKRPNPELRRNMTIKTELPLGARRKMKPLLPRVSSYLVPIQFPVNQSLVLQPSVKVPLPLAASLMSSELARHSKRVRIAPKVLLAEEGIAPLSSAGPGKEEKLLFGEGFSPLLPVQTIKEEEIQPGEEMPHLARPIKVESPPLEEWPSPAPSFKEESSHSWEDSSQSPTPRPKKSYSGLRSPTRCVSEMLVIQHRERRERSRSRRKQHLLPPCVDEPELLFSEGPSTSRWAAELPFPADSSDPASQLSYSQEVGGPFKTPIKETLPISSTPSKSVLPRTPESWRLTPPAKVGGLDFSPVQTSQGASDPLPDPLGLMDLSTTPLQSAPPLESPQRLLSSEPLDLISVPFGNSSPSDIDVPKPGSPEPQVSGLAANRSLTEGLVLDTMNDSLSKILLDISFPGLDEDPLGPDNINWSQFIPELQ
  
Inhibitor
Name:
BDBM50085045
Synonyms:
5-((4-((6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-chromen-2-yl)methoxy)phenyl)methyl)thiazolidine-2,4-dione | 5-(4-((6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)methoxy)benzyl)thiazolidine-2,4-dione | 5-[4-(6-Hydroxy-2,5,7,8-tetramethyl-chroman-2-ylmethoxy)-benzy l]-thiazolidine-2,4-dione (troglitazone) | 5-[4-(6-Hydroxy-2,5,7,8-tetramethyl-chroman-2-ylmethoxy)-benzyl]-thiazolidine-2,4-dione | 5-[4-(6-Hydroxy-2,5,7,8-tetramethyl-chroman-2-ylmethoxy)-benzyl]-thiazolidine-2,4-dione(troglitazone) | 5-[4-(6-Hydroxy-2,5,7,8-tetramethyl-chroman-2-ylmethoxy)-benzyl]-thiazolidine-2,4-dioneTroglitazone | CHEMBL408 | CI-991 | CS-045 | GR92132X | PRELAY | REZULIN | TROGLITAZONE
Type:
Small organic molecule
Emp. Form.:
C24H27NO5S
Mol. Mass.:
441.54
SMILES:
Cc1c(C)c2OC(C)(COc3ccc(Cc4sc(=O)[nH]c4O)cc3)CCc2c(C)c1O
Structure:
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