Target
Tyrosine-protein kinase Lck
Ligand
BDBM50126756
Substrate
n/a
Meas. Tech.
ChEMBL_221314 (CHEMBL841204)
IC50
50±n/a nM
Citation
 Goldberg, DRButz, TCardozo, MGEckner, RJHammach, AHuang, JJakes, SKapadia, SKashem, MLukas, SMorwick, TMPanzenbeck, MPatel, UPav, SPeet, GWPeterson, JDProkopowicz, ASSnow, RJSellati, RTakahashi, HTan, JTschantz, MAWang, XJWang, YWolak, JXiong, PMoss, N Optimization of 2-phenylaminoimidazo[4,5-h]isoquinolin-9-ones: orally active inhibitors of lck kinase. J Med Chem 46:1337-49 (2003) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase Lck
Synonyms:
2.7.10.2 | LCK | LCK_HUMAN | LSK | Leukocyte C-terminal Src kinase | Lymphocyte cell-specific protein-tyrosine kinase | Lymphocyte-specific protein tyrosine kinase | P56-LCK | Protein YT16 | Proto-oncogene Lck | Proto-oncogene tyrosine-protein kinase LCK | Src/Lck kinase | T cell-specific protein-tyrosine kinase
Type:
n/a
Mol. Mass.:
57987.83
Organism:
Homo sapiens (Human)
Description:
P06239
Residue:
509
Sequence:
MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP
  
Inhibitor
Name:
BDBM50126756
Synonyms:
2-(2,6-Dichloro-phenylamino)-4-(2,6-difluoro-pyridin-3-yl)-1,6,7-trimethyl-1,8-dihydro-imidazo[4,5-h]isoquinolin-9-one | CHEMBL26625
Type:
Small organic molecule
Emp. Form.:
C24H17Cl2F2N5O
Mol. Mass.:
500.327
SMILES:
Cc1[nH]c(=O)c2c3n(C)c(Nc4c(Cl)cccc4Cl)nc3c(cc2c1C)-c1ccc(F)nc1F
Structure:
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