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Target
Carbonic anhydrase 6
Ligand
BDBM50562972
Substrate
n/a
Meas. Tech.
ChEMBL_2081162 (CHEMBL4736953)
Ki
11±n/a nM
Citation
 Mboge, MY; Combs, J; Singh, S; Andring, J; Wolff, A; Tu, C; Zhang, Z; McKenna, R; Frost, SC Inhibition of Carbonic Anhydrase Using SLC-149: Support for a Noncatalytic Function of CAIX in Breast Cancer. J Med Chem 64:1713-1724 (2021) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 6
Synonyms:
CA-VI | CA6 | CAH6_HUMAN | Carbonate dehydratase VI | Carbonic Anhydrase VI | Carbonic anhydrase | Carbonic anhydrase 6 | Carbonic anhydrase 6 (CA VI) | Carbonic anhydrase 6 (CA-VI) | Carbonic anhydrase VI (CA VI) | Salivary carbonic anhydrase | Secreted carbonic anhydrase
Type:
Enzyme
Mol. Mass.:
35371.40
Organism:
Homo sapiens (Human)
Description:
P23280
Residue:
308
Sequence:
MRALVLLLSLFLLGGQAQHVSDWTYSEGALDEAHWPQHYPACGGQRQSPINLQRTKVRYNPSLKGLNMTGYETQAGEFPMVNNGHTVQISLPSTMRMTVADGTVYIAQQMHFHWGGASSEISGSEHTVDGIRHVIEIHIVHYNSKYKSYDIAQDAPDGLAVLAAFVEVKNYPENTYYSNFISHLANIKYPGQRTTLTGLDVQDMLPRNLQHYYTYHGSLTTPPCTENVHWFVLADFVKLSRTQVWKLENSLLDHRNKTIHNDYRRTQPLNHRVVESNFPNQEYTLGSEFQFYLHKIEEILDYLRRALN
  
Inhibitor
Name:
BDBM50562972
Synonyms:
CHEMBL4799997
Type:
Small organic molecule
Emp. Form.:
C15H13F2N3O3S
Mol. Mass.:
353.344
SMILES:
NS(=O)(=O)c1ccc(cc1)N1CCN(C1=O)c1ccc(F)cc1F
Structure:
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