Target
ATP-sensitive inward rectifier potassium channel 11
Ligand
BDBM50127764
Substrate
n/a
Meas. Tech.
ChEBML_92724
EC50
46±n/a nM
Citation
 Turner, SCCarroll, WAWhite, TKBrune, MEBuckner, SAGopalakrishnan, MFabiyi, ACoghlan, MJScott, VECastle, NADaza, AVMilicic, ISullivan, JP Structure-activity relationship of a novel class of naphthyl amide KATP channel openers. Bioorg Med Chem Lett 13:1741-4 (2003) [PubMed]  Article 
Target
Name:
ATP-sensitive inward rectifier potassium channel 11
Synonyms:
ATP-sensitive inward rectifier potassium channel 11 | IKATP | Inward rectifier K(+) channel Kir6.2 | KCJ11_HUMAN | KCNJ11 | Potassium channel, inwardly rectifying subfamily J member 11 | Potassium channel, inwardly rectifying, subfamily J, member 11 | Sulfonylurea receptor 1, Kir6.2 | Sulfonylurea receptor 2, Kir6.2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
43549.41
Organism:
Homo sapiens (Human)
Description:
Potassium channel (ATP modulatory) 0 0::Q14654
Residue:
390
Sequence:
MLSRKGIIPEEYVLTRLAEDPAEPRYRARQRRARFVSKKGNCNVAHKNIREQGRFLQDVFTTLVDLKWPHTLLIFTMSFLCSWLLFAMAWWLIAFAHGDLAPSEGTAEPCVTSIHSFSSAFLFSIEVQVTIGFGGRMVTEECPLAILILIVQNIVGLMINAIMLGCIFMKTAQAHRRAETLIFSKHAVIALRHGRLCFMLRVGDLRKSMIISATIHMQVVRKTTSPEGEVVPLHQVDIPMENGVGGNSIFLVAPLIIYHVIDANSPLYDLAPSDLHHHQDLEIIVILEGVVETTGITTQARTSYLADEILWGQRFVPIVAEEDGRYSVDYSKFGNTIKVPTPLCTARQLDEDHSLLEALTLASARGPLRKRSVPMAKAKPKFSISPDSLS
  
Inhibitor
Name:
BDBM50127764
Synonyms:
3-Methyl-but-2-enoic acid [2-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-naphthalen-1-yl]-amide | CHEMBL300969
Type:
Small organic molecule
Emp. Form.:
C18H15F6NO2
Mol. Mass.:
391.3076
SMILES:
[#6]\[#6](-[#6])=[#6]\[#6](=O)-[#7]-c1c(ccc2ccccc12)C([#8])(C(F)(F)F)C(F)(F)F
Structure:
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