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Target
Ecdysone receptor
Ligand
BDBM50128476
Substrate
n/a
Meas. Tech.
ChEBML_65453
EC50
33300±n/a nM
Citation
 Smith, HC; Cavanaugh, CK; Friz, JL; Thompson, CS; Saggers, JA; Michelotti, EL; Garcia, J; Tice, CM Synthesis and SAR of cis-1-benzoyl-1,2,3,4-tetrahydroquinoline ligands for control of gene expression in ecdysone responsive systems. Bioorg Med Chem Lett 13:1943-6 (2003) [PubMed]  Article 
Target
Name:
Ecdysone receptor
Synonyms:
20-hydroxy-ecdysone receptor | 20E receptor | AaEcR | ECR_AEDAE | EcR | EcRH | Ecdysteroid receptor | NR1H1 | Nuclear receptor subfamily 1 group H member 1
Type:
PROTEIN
Mol. Mass.:
83656.95
Organism:
Aedes aegypti
Description:
ChEMBL_65453
Residue:
776
Sequence:
MYRLNIVSTNPSGSVQQQQQAQGQQVISSVVRPQQQQPPPQLALVQTGGSGGTTTTIIGLTSLNALNATTITGLVAGAAGSSTSAIAAAGASNSGSGPSTATTKHILKAATTNNNISIVKIVDDIMLKAVKVEPLPMDTGGGGGGVSMIPSSATTSGGVTVTAIPASVAPMPPVAAGTNVSSNGSVTVYASGKRRLESNEEWISSPSPGSVPGSAPPLSPSPGSQSTTYTTTMSNGYSSPMSTGSYDPYSPNGKMGREDLSPSSSLNGYTDGSDAKKQKKGPTPRQQEELCLVCGDRESGYHYNALTCEGCKGFFRRSVTKNAVYCCKFGHACEMDMYMRRKCQECRLKKCLAVGMRPECVVPENQCAIKRKEKKAQKEKDKVQTNATVSTTNSTYRSEILPILMKCDPPPHQAIPLLPEKLLQENRLRNIPLLTANQMAVIYKLIWYQDGYEQPSEEDLKRIMIGSPNEEEDQHDVHFRHITEITILTVQLIVEFAKGLPAFTKIPQEDQITLLKACSSEVMMLRMARRYDAATDSILFANNRSYTRDSYRMAGMADTIEDLLHFCRQMFSLTVDNVEYALLTAIVIFSDRPGLEQAELVEHIQSYYIDTLRIYILNRHAGDPKCSVIFAKLLSILTELRTLGNQNSEMCFSLKLKNRKLPRFLEEIWDVQDIPPSMQAQMHSHGTQSSSSSSSSSSSSSNGSSNGNSSSNSNSSQHGPHPHPHGQQLTPNQQQHQQQHSQLQQVHANGSGSGGGSNNNSSSGGVVPGLGMLDQV
  
Inhibitor
Name:
BDBM50128476
Synonyms:
CHEMBL61369 | [(2R,4S)-6-Fluoro-4-(4-fluoro-phenylamino)-2-methyl-3,4-dihydro-2H-quinolin-1-yl]-(2-methoxy-phenyl)-methanone
Type:
Small organic molecule
Emp. Form.:
C24H22F2N2O2
Mol. Mass.:
408.4405
SMILES:
COc1ccccc1C(=O)N1[C@H](C)C[C@H](Nc2ccc(F)cc2)c2cc(F)ccc12
Structure:
Search PDB for entries with ligand similarity: