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Target
Inosine-5'-monophosphate dehydrogenase 2
Ligand
BDBM50129120
Substrate
n/a
Meas. Tech.
ChEBML_89803
IC50
210±n/a nM
Citation
 Iwanowicz, EJ; Watterson, SH; Guo, J; Pitts, WJ; Murali Dhar, TG; Shen, Z; Chen, P; Gu, HH; Fleener, CA; Rouleau, KA; Cheney, DL; Townsend, RM; Hollenbaugh, DL Inhibitors of inosine monophosphate dehydrogenase: SARs about the N-[3-Methoxy-4-(5-oxazolyl)phenyl moiety. Bioorg Med Chem Lett 13:2059-63 (2003) [PubMed]  Article 
Target
Name:
Inosine-5'-monophosphate dehydrogenase 2
Synonyms:
IMDH2_HUMAN | IMP dehydrogenase 2 | IMPD 2 | IMPD2 | IMPDH-II | IMPDH2 | Inosine 5'-monophosphate dehydrogenase II (IMPDH II) | Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2) | Inosine-5 -monophosphate dehydrogenase 2 | Inosine-5'-monophosphate dehydrogenase (IMPDH)
Type:
Enzyme
Mol. Mass.:
55806.87
Organism:
Homo sapiens (Human)
Description:
Recombinant IMPDH2 expressed in E. coli.
Residue:
514
Sequence:
MADYLISGGTSYVPDDGLTAQQLFNCGDGLTYNDFLILPGYIDFTADQVDLTSALTKKITLKTPLVSSPMDTVTEAGMAIAMALTGGIGFIHHNCTPEFQANEVRKVKKYEQGFITDPVVLSPKDRVRDVFEAKARHGFCGIPITDTGRMGSRLVGIISSRDIDFLKEEEHDCFLEEIMTKREDLVVAPAGITLKEANEILQRSKKGKLPIVNEDDELVAIIARTDLKKNRDYPLASKDAKKQLLCGAAIGTHEDDKYRLDLLAQAGVDVVVLDSSQGNSIFQINMIKYIKDKYPNLQVIGGNVVTAAQAKNLIDAGVDALRVGMGSGSICITQEVLACGRPQATAVYKVSEYARRFGVPVIADGGIQNVGHIAKALALGASTVMMGSLLAATTEAPGEYFFSDGIRLKKYRGMGSLDAMDKHLSSQNRYFSEADKIKVAQGVSGAVQDKGSIHKFVPYLIAGIQHSCQDIGAKSLTQVRAMMYSGELKFEKRTSSAQVEGGVHSLHSYEKRLF
  
Inhibitor
Name:
BDBM50129120
Synonyms:
7-Methoxy-6-oxazol-4-yl-2-phenyl-1H-quinolin-4-one | CHEMBL65738
Type:
Small organic molecule
Emp. Form.:
C19H14N2O3
Mol. Mass.:
318.3261
SMILES:
COc1cc2nc(cc(O)c2cc1-c1cocn1)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: