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Target
Growth factor receptor-bound protein 2
Ligand
BDBM50129420
Substrate
n/a
Meas. Tech.
ChEBML_72354
IC50
149±n/a nM
Citation
 Li, P; Zhang, M; Long, YQ; Peach, ML; Liu, H; Yang, D; Nicklaus, M; Roller, PP Potent Grb2-SH2 domain antagonists not relying on phosphotyrosine mimics. Bioorg Med Chem Lett 13:2173-7 (2003) [PubMed]  Article 
Target
Name:
Growth factor receptor-bound protein 2
Synonyms:
ASH | GRB2 | GRB2 adapter protein | GRB2_HUMAN | Grb2-SH2 | Growth factor receptor-bound protein 2
Type:
Protein
Mol. Mass.:
25205.04
Organism:
Homo sapiens (Human)
Description:
P62993
Residue:
217
Sequence:
MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
  
Inhibitor
Name:
BDBM50129420
Synonyms:
(R)-cyclic ((N-AC)Gla Leu Tyr Ach Asn Val Gly Cha Tyr Cys(O) NH2) | (S)-cyclic ((N-AC)Gla Leu Tyr Ach Asn Val Gly Cha Tyr Cys(O) NH2) | CHEMBL406289
Type:
Small organic molecule
Emp. Form.:
C61H86N12O19S
Mol. Mass.:
1323.47
SMILES:
CC(C)C[C@H]1NC(=O)[C@H](CC(C(O)=O)C(O)=O)NC(=O)CS(=O)C[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](NC(=O)CNC(=O)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)C2(CCCCC2)NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O)C(C)C)C1CCCCC1)C(N)=O
Structure:
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