Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 2A
Ligand
BDBM50130081
Substrate
n/a
Meas. Tech.
ChEBML_2293
Ki
4.1±n/a nM
Citation
 Ennis, MD; Hoffman, RL; Ghazal, NB; Olson, RM; Knauer, CS; Chio, CL; Hyslop, DK; Campbell, JE; Fitzgerald, LW; Nichols, NF; Svensson, KA; McCall, RB; Haber, CL; Kagey, ML; Dinh, DM 2,3,4,5-tetrahydro- and 2,3,4,5,11,11a-hexahydro-1H-[1,4]diazepino[1,7-a]indoles: new templates for 5-HT(2C) agonists. Bioorg Med Chem Lett 13:2369-72 (2003) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 2A
Synonyms:
5-HT-2 | 5-HT-2A | 5-HT2A | 5-hydroxytryptamine receptor 2A (5-HT-2A) | 5-hydroxytryptamine receptor 2A (5HT-2A) | 5-hydroxytryptamine receptor 2A (5HT2A) | 5HT2A_HUMAN | HTR2 | HTR2A | Serotonin receptor 2A
Type:
undefined
Mol. Mass.:
52607.65
Organism:
Homo sapiens (Human)
Description:
P28223
Residue:
471
Sequence:
MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV
  
Inhibitor
Name:
BDBM50130081
Synonyms:
1,2,8,9,10,11-Hexahydro-7H-3-oxa-9,11b-diaza-cyclohepta[a]acenaphthylene | CHEMBL76494 | PHA-57378
Type:
Small organic molecule
Emp. Form.:
C14H16N2O
Mol. Mass.:
228.2896
SMILES:
C1Cn2c3CCNCCc3c3cccc(O1)c23
Structure:
Search PDB for entries with ligand similarity: